Evaluation of FOXC1 as a therapeutic target for basal-like breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-018-0010-9
Abstract: Basal-like breast cancer (BLBC) is a malignant carcinoma with aggressive motility and rapid growth. Accounting for 15% of breast cancers, BLBC often exhibits a poor prognosis and tends to metastasize to the brain and lungs.… read more here.
Keywords: breast; blbc; foxc1; cancer ... See more keywords
Exploring ID4 as a driver of aggression and a therapeutic target in triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-025-00787-y
Abstract: Basal-like breast cancer (BLBC) is characterized by an aggressive clinical course, high genomic instability, and limited therapeutic options. The Inhibitor of Differentiation 4 (ID4) protein has been identified as a critical regulator of BLBC, where… read more here.
Keywords: id4; cancer; blbc; breast cancer ... See more keywords
Decoding the link between WWOX and p53 in aggressive breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1616998
Abstract: ABSTRACT Basal-like breast cancer (BLBC) and triple-negative breast cancer (TNBC) are aggressive forms of human breast cancer with poor prognosis and limited treatment response. Molecular understanding of BLBC and TNBC biology is instrumental to improve… read more here.
Keywords: blbc; wwox p53; breast; breast cancer ... See more keywords
PO-300 CIP2A-mediated regulation of senescence in basal-like breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.813
Abstract: Introduction Basal-like breast cancer (BLBC) is an aggressive breast cancer molecular subtype, and it lacks efficient therapy options. Expression levels of oncoprotein CIP2A are increased in BLBC as compared to other breast cancer subtypes. Our… read more here.
Keywords: blbc; senescence; cip2a; breast cancer ... See more keywords
FOXC1 Expression Predicts Capecitabine Efficacy in Patients with Triple-Negative Breast Cancer from the GEICAM_CIBOMA Trial
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-25-0338
Abstract: Abstract Purpose: In a prespecified GEICAM_CIBOMA trial (NCT00130533) correlative analysis, PAM50 non–basal-like breast cancer (non-BLBC) status distinguished patients with triple-negative breast cancer (TNBC) who are most likely to benefit from adjuvant capecitabine. The standardized forkhead… read more here.
Keywords: blbc; cancer; geicam ciboma; trial ... See more keywords
Tumorigenicity of EGFR- and/or HER2-Positive Breast Cancers Is Mediated by Recruitment of Tumor-Associated Macrophages
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021443
Abstract: Basal-like breast cancer (BLBC) has a clinically aggressive nature. It is prevalent in young women and is known to often relapse rapidly. To date, the molecular mechanisms regarding the aggressiveness of BLBC have not been… read more here.
Keywords: breast; her2; egfr her2; blbc ... See more keywords
Targeting the KLF5-EphA2 axis can restrain cancer stemness and overcome chemoresistance in basal-like breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.82567
Abstract: Ephrin type-A receptor 2 (EphA2) is a member of the tyrosine receptor kinases, a family of membrane proteins recognized as potential anticancer targets. EphA2 highly expressed in a variety of human cancers, playing roles in… read more here.
Keywords: klf5 epha2; stemness; breast cancer; blbc ... See more keywords
Nuclear translocation of PLSCR1 activates STAT1 signaling in basal-like breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.43150
Abstract: Rationale: Basal-like breast cancer (BLBC) is associated with high grade, distant metastasis, and poor prognosis; however, the mechanism underlying aggressiveness of BLBC is still unclear. Emerging evidence has suggested that phospholipid scramblase 1 (PLSCR1) is… read more here.
Keywords: blbc; breast cancer; plscr1; cancer ... See more keywords