Circ_0002099 is a novel molecular therapeutic target for bladder cancer
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.22005
Abstract: Bladder cancer (BLCA) acts as one of the most common malignant tumors in the urinary system without ideal therapy. We performed the present study to explore the role and mechanism of Circ_0002099 in BLCA progression.… read more here.
Keywords: blca progression; bladder cancer; circ 0002099; blca ... See more keywords
NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23796
Abstract: PURPOSE This study identified the function of neural precursor cell expressed developmentally down-regulated 4-like (NEDD4L) on bladder cancer (BLCA). METHODS NEDD4L expression in BLCA patients was scrutinized. The function of NEDD4L on the viability, apoptosis,… read more here.
Keywords: p62 keap1; nrf2 pathway; blca; keap1 nrf2 ... See more keywords
Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress
Sign Up to like & getrecommendations! Published in 2020 at "Oncogenesis"
DOI: 10.1038/s41389-020-0230-3
Abstract: Cancer cells adapt to nutrient-deprived tumor microenvironment during progression via regulating the level and function of metabolic enzymes. Acetyl-coenzyme A (AcCoA) is a key metabolic intermediate that is crucial for cancer cell metabolism, especially under… read more here.
Keywords: metabolic stress; stress; blca; cancer cell ... See more keywords
Artificial Intelligence Meets Whole Slide Images: Deep Learning Model Shapes an Immune-Hot Tumor and Guides Precision Therapy in Bladder Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/8213321
Abstract: Background To construct and validate a deep learning cluster from whole slide images (WSI) for depicting the immunophenotypes and functional heterogeneity of the tumor microenvironment (TME) in patients with bladder cancer (BLCA) and to explore… read more here.
Keywords: whole slide; deep learning; slide images; wsi cluster ... See more keywords
Abstract 4316: Disruption and restoration of pioneer transcription factor hub function in bladder cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4316
Abstract: Urothelial bladder cancer is characterized by the failure to complete transitional epithelial-differentiation. The mechanisms underlying this failure are unknown. To address this gap in knowledge, we analyzed 2000 genes differentially expressed between normal bladder vs.… read more here.
Keywords: bladder cancer; function; bladder; blca ... See more keywords
A novel signature constructed by ferroptosis-associated genes (FAGs) for the prediction of prognosis in bladder urothelial carcinoma (BLCA) and associated with immune infiltration
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02096-3
Abstract: Background Ferroptosis, a novel form of regulated cell death, has been implicated in the pathogenesis of cancers. Nevertheless, the potential function and prognostic values of ferroptosis in bladder urothelial carcinoma (BLCA) are complex and remain… read more here.
Keywords: analysis; ferroptosis associated; blca; signature ... See more keywords
Global analysis of miRNA-mRNA regulation pair in bladder cancer
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Surgical Oncology"
DOI: 10.1186/s12957-022-02538-w
Abstract: Purpose MicroRNA (miRNA) is a class of short non-coding RNA molecules that functions in RNA silencing and post-transcriptional regulation of gene expression. This study aims to identify critical miRNA-mRNA regulation pairs contributing to bladder cancer… read more here.
Keywords: mrna regulation; blca; regulation; mirna mrna ... See more keywords
Risk score based on three mRNA expression predicts the survival of bladder cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18642
Abstract: Bladder cancer (BLCA) is one of the most malignant cancers worldwide, and its prognosis varies. 1214 BLCA samples in five different datasets and 2 platforms were enrolled in this study. By utilizing the gene expression… read more here.
Keywords: risk; risk score; expression; blca ... See more keywords
Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21038
Abstract: High-grade Bladder Cancer (BLCA) represents the most aggressive and treatment-resistant cancer that renders the patients with poor survival. However, only a few biomarkers have been identified for the detection and treatment of BLCA. Recent studies… read more here.
Keywords: bladder cancer; gd2; blca; cancer ... See more keywords
Analysis of potential genes associated with primary cilia in bladder cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Management and Research"
DOI: 10.2147/cmar.s175419
Abstract: Background Dysfunction of primary cilia (PC), which could influence cell cycle and modulate cilia-related signaling transduction, has been reported in several cancers. However, there is no evidence of their function in bladder cancer (BLCA). This… read more here.
Keywords: bladder cancer; ontology; analysis; blca ... See more keywords
CDKN3 Overcomes Bladder Cancer Cisplatin Resistance via LDHA-Dependent Glycolysis Reprogramming
Sign Up to like & getrecommendations! Published in 2022 at "OncoTargets and therapy"
DOI: 10.2147/ott.s358008
Abstract: Background Aerobic glycolysis plays an important role in bladder cancer (BLCA) progression and chemoresistance. Cyclin-dependent kinase inhibitor-3 (CDKN3), a dual-specificity protein tyrosine phosphatase, has aberrant upregulation in multiple cancer types and is associated with tumorigenesis.… read more here.
Keywords: cdkn3; glycolysis; bladder cancer; chemoresistance ... See more keywords