Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202303370
Abstract: The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic lipid component. LNP mRNA systems composed of optimized ionizable lipids often display distinctive mRNA rich "bleb" structures. Here we… read more here.
Keywords: improved transfection; transfection potency; potency; lipid nanoparticle ... See more keywords
Three-year outcomes of surgical bleb revision with mitomycin C for early scarring bleb after trabeculectomy
Sign Up to like & getrecommendations! Published in 2024 at "Japanese Journal of Ophthalmology"
DOI: 10.1007/s10384-024-01142-7
Abstract: To report the 3-year outcomes of surgical bleb revision (SBR) with mitomycin C (MMC) for early scarring bleb after trabeculectomy (TLE). Retrospective observational study. We included glaucoma patients aged ≧ 18 who underwent SBR with… read more here.
Keywords: early scarring; glaucoma; success; three year ... See more keywords
A new technique for encapsulated filtration blebs: Vitrector assisted cystectomy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal francais d'ophtalmologie"
DOI: 10.1016/j.jfo.2016.11.030
Abstract: We introduce a new technique for the management of encapsulated non filtering blebs which are unresponsive to needling procedure. A 21 year-old man with a visual acuity of 20/30 presented with encapsulated bleb in the… read more here.
Keywords: bleb; assisted cystectomy; new technique; vitrector assisted ... See more keywords
Evaluation of Bleb Fluid After Baerveldt Glaucoma Implantation Using Magnetic Resonance Imaging
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11054-x
Abstract: We evaluated bleb fluid images taken after Baerveldt glaucoma implantation. T2-weighted images of bleb fluid were scanned with 3 Tesla magnetic resonance imaging in 52 patients who had undergone tube-shunt surgery using the 350-mm2 endplate… read more here.
Keywords: bleb fluid; bleb; bleb layer; baerveldt glaucoma ... See more keywords
Preliminary experimental study on a novel device using biomaterial for shunting fibrotic bleb following Ahmed glaucoma valve surgery in dogs
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-86480-3
Abstract: This study aimed to design and evaluate a novel trans-bleb device (TBD) for draining aqueous humor trapped within fibrotic blebs following Ahmed glaucoma valve (AGV) implantation in dogs. Two clinically normal, purpose-bred Beagles underwent AGV… read more here.
Keywords: surgery; ahmed glaucoma; bleb; following ahmed ... See more keywords
Mitomycin C-loaded PTMC15–F127–PTMC15 hydrogel maintained better bleb function after filtering glaucoma surgery in monkeys with intraocular hypertension
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra01002c
Abstract: There is an unmet need for a safer and more effective approach for antimetabolite application to prevent bleb fibrosis after glaucoma filtering surgery. Here, we utilized our previously developed thermosensitive sustained-release agent, mitomycin C-loaded poly(trimethylene… read more here.
Keywords: glaucoma; hydrogel; surgery; mmc hydrogel ... See more keywords
Blebbistatin modulates prostatic cell growth and contrapctility through myosin II signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical science"
DOI: 10.1042/cs20180294
Abstract: To investigate the effect of blebbistatin (BLEB, a selective myosin inhibitor) on regulating contractility and growth of prostate cells and to provide insight into possible mechanisms associated with these actions. BLEB was incubated with cell… read more here.
Keywords: bleb; myosin; blebbistatin; cell growth ... See more keywords
Comparison of Anterior Segment Optical Coherence Tomography Bleb Grading, Moorfields Bleb Grading System, and Intraocular Pressure After Trabeculectomy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Glaucoma"
DOI: 10.1097/ijg.0000000000000636
Abstract: Purpose: To compare a novel anterior segment optical coherence tomography (AS-OCT) bleb grading system with a clinical bleb grading system and both with intraocular pressure (IOP) following trabeculectomy surgery. Materials and Methods: A novel AS-OCT… read more here.
Keywords: bleb; moorfields bleb; bleb grading; grading system ... See more keywords
A Novel Hinged Scleral Patch Graft for the Repair of Overfiltration and Bleb Leaks
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Glaucoma"
DOI: 10.1097/ijg.0000000000000882
Abstract: Introduction: The repair of the scleral flap is often needed in cases of severe hypotony or bleb leaks with overfiltration. We present a simple novel technique to restore the hinged flap using a scleral patch… read more here.
Keywords: scleral patch; bleb; patch graft; bleb leaks ... See more keywords
Impact of Cataract Surgery on Filtering Bleb Morphology Identified Via Swept-source 3-dimensional Anterior Segment Optical Coherence Tomography
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Glaucoma"
DOI: 10.1097/ijg.0000000000001204
Abstract: Précis: Analysis of filtering bleb morphology using swept-source 3-dimensional anterior segment optical coherence tomography (3D AS-OCT) indicates that phacoemulsification can negatively impact the morphology of preexisting filtering blebs. Purpose: To identify the cross-sectional morphologic changes… read more here.
Keywords: filtering bleb; swept source; bleb; group ... See more keywords
Bleb morphology of glaucoma drainage devices on magnetic resonance imaging.
Sign Up to like & getrecommendations! Published in 2023 at "Acta ophthalmologica"
DOI: 10.1111/aos.15668
Abstract: PURPOSE To evaluate bleb morphology features of different glaucoma drainage devices (GDD) using magnetic resonance imaging (MRI). MATERIALS AND METHODS Prospective cohort study of GDD and bleb morphology in consecutive glaucoma patients implanted with Ahmed… read more here.
Keywords: bleb; bleb morphology; bleb volume; glaucoma ... See more keywords