Blebbistatin, a Myosin II Inhibitor, Exerts Antidepressant-Like Activity and Suppresses Detrusor Overactivity in an Animal Model of Depression Coexisting with Overactive Bladder
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DOI: 10.1007/s12640-018-9948-5
Abstract: Overactive bladder (OAB) coexists with depression in women. Here, we assessed the effects of a 1-week treatment with blebbistatin, a myosin II inhibitor, on changes in behavior and detrusor overactivity (DO) symptoms induced by a… read more here.
Keywords: blebbistatin; overactive bladder; bladder; myosin inhibitor ... See more keywords
Dissecting Actomyosin Mechanochemistry using Blebbistatin as a Pharmacological Tool
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DOI: 10.1016/j.bpj.2016.11.657
Abstract: Muscle contraction results from cyclic interactions between actin and myosin under turnover of ATP. Here, we use the myosin II-specific inhibitor blebbistatin as a pharmacological tool to elucidate this interaction. Particularly we consider the hypotheses… read more here.
Keywords: pharmacological tool; blebbistatin; muscle; blebbistatin pharmacological ... See more keywords
Blebbistatin modulates prostatic cell growth and contrapctility through myosin II signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical science"
DOI: 10.1042/cs20180294
Abstract: To investigate the effect of blebbistatin (BLEB, a selective myosin inhibitor) on regulating contractility and growth of prostate cells and to provide insight into possible mechanisms associated with these actions. BLEB was incubated with cell… read more here.
Keywords: bleb; myosin; blebbistatin; cell growth ... See more keywords
Blebbistatin Inhibits Neomycin-Induced Apoptosis in Hair Cell-Like HEI-OC-1 Cells and in Cochlear Hair Cells
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DOI: 10.3389/fncel.2019.00590
Abstract: Aging, noise, and ototoxic drug-induced hair cell (HC) loss are the major causes of sensorineural hearing loss. Aminoglycoside antibiotics are commonly used in the clinic, but these often have ototoxic side effects due to the… read more here.
Keywords: blebbistatin; apoptosis; hair; like hei ... See more keywords
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
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DOI: 10.7554/elife.83602
Abstract: The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at… read more here.
Keywords: pocket opening; blebbistatin; pocket; motor ... See more keywords