Absence of impact of hypovitaminosis C on the bleeding phenotype of primary immune thrombocytopenia: a French prospective multicenter study
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DOI: 10.1080/09537104.2020.1732326
Abstract: Immune thrombocytopenia (ITP) is defined by a decreased platelet count (PC) leading to an increased risk of bleeding. Common hemorrhagic symptoms include bruising, purpura and petechiae, whereas se... read more here.
Keywords: absence impact; thrombocytopenia; hypovitaminosis bleeding; impact hypovitaminosis ... See more keywords
Evaluation of Bleeding Phenotype of Inherited Factor VII Deficiency in Children With a Bleeding Assessment Tool and Global Assays
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DOI: 10.1097/mph.0000000000001564
Abstract: Introduction: Inherited factor VII (FVII) deficiency is the most common of the rare bleeding disorders and shows a heterogenous distribution of bleeding phenotypes independent of factor activity level. The bleeding score (BS) evaluates the phenotype… read more here.
Keywords: global assays; deficiency; factor; bleeding phenotype ... See more keywords
Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients
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DOI: 10.1111/bjh.18145
Abstract: Von Willebrand disease (VWD) is a bleeding disorder caused by quantitative (type 1 or 3) or qualitative (type 2A/2B/2M/2N) defects of circulating von Willebrand factor (VWF). Circulating VWF levels not always fully explain bleeding phenotypes,… read more here.
Keywords: platelet degranulation; willebrand; willebrand disease; large cohort ... See more keywords
Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality.
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2019.218818
Abstract: Tissue factor is highly expressed in sub-endothelial tissue. The extracellular allosteric disulfide bond Cys186-Cys209 of human tissue factor shows high evolutionary conservation and in vitro evidence suggests that it significantly contributes to tissue factor procoagulant… read more here.
Keywords: tissue factor; pathology; tissue; bleeding phenotype ... See more keywords