Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.08.004
Abstract: BACKGROUND There is growing evidence that vasculopathy-induced hypoxia and oxidative stress enhance the process of fibrosis in systemic sclerosis (SSc). Kaempferol is a natural flavonoid widely found in various vegetables and fruits, and has been… read more here.
Keywords: fibrosis; bleomycin; kaempferol; skin ... See more keywords
Histopathological Impact of Bleomycin on Lung Injury and Development of Mediastinal Fat-Associated Lymphoid Clusters in the Lymphoproliferative Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927622000654
Abstract: Abstract The purpose of this study is to elucidate the impact of bleomycin on the degree of lung injury and development of mediastinal fat-associated lymphoid clusters (MFALCs) in the lymphoproliferative mouse model (MRL/MpJ-Faslpr/lpr “Lpr”) and… read more here.
Keywords: lung injury; development; lung; bleomycin ... See more keywords
Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c20479
Abstract: Bleomycins (BLMs) are widely used in clinics as antitumor agents. However, BLM-based chemotherapies often accompany severe pulmonary fibrosis (PF). Human bleomycin hydrolase is a cysteine protease that can convert BLMs into inactive deamido-BLMs. In this… read more here.
Keywords: mannose modified; bleomycin hydrolase; pulmonary fibrosis; bleomycin ... See more keywords
Multi-gram scale synthesis of a bleomycin (BLM) carbohydrate moiety: exploring the antitumor beneficial effect of BLM disaccharide attached to 10-hydroxycamptothecine (10-HCPT)
Sign Up to like & getrecommendations! Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c8nj06191b
Abstract: An efficient multi-gram synthesis of bleomycin disaccharide has been developed, and its conjugate with 10-HCPT displayed obvious selectivity, clearly indicating the potential of bleomycin disaccharide in solving the targeted therapy of cytotoxic drugs. read more here.
Keywords: synthesis bleomycin; blm; bleomycin; multi gram ... See more keywords
Electrochemotherapy with intravenous bleomycin for patients with cutaneous malignancies, across tumour histology: a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Acta Oncologica"
DOI: 10.1080/0284186x.2022.2110385
Abstract: Abstract Background Electrochemotherapy (ECT) is an established treatment for primary and secondary cutaneous tumours. The method combines chemotherapy with electroporation, thus increasing the cytotoxic effect of the chemotherapeutic drug. Bleomycin is the drug of choice… read more here.
Keywords: patients cutaneous; histology; bleomycin patients; bleomycin ... See more keywords
Histopathological, physiological and biochemical assessment of resveratrol nanocapsules efficacy in bleomycin-induced acute and chronic lung injury in rats
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2105445
Abstract: Abstract Acute lung injury (ALI) is a life-threatening illness which may progress to chronic pulmonary fibrosis (CPF). Resveratrol (RSV), a natural polyphenol, is known to exert several pharmacological effects on lung injury. However, its physicochemical… read more here.
Keywords: bleomycin; lncs; rsv lncs; lung injury ... See more keywords
Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2017.1409405
Abstract: ABSTRACT Bleomycin is a clinically potent anticancer drug used for the treatment of germ-cell tumors, lymphomas and squamous-cell carcinomas. Unfortunately, the therapeutic efficacy of bleomycin is severely hampered by the development of pulmonary fibrosis. However,… read more here.
Keywords: fibrosis; bleomycin; target; autophagic flux ... See more keywords
9 Understanding how CeO2 Nanoparticles Modulate Bleomycin-Induced Inflammatory and Fibrotic Events in Both in Vivo and in Vitro Models
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Work Exposures and Health"
DOI: 10.1093/annweh/wxac087.102
Abstract: Cerium oxide nanoparticles (CeO2NPs) from some diesel fuel additives and other applications have been detected in ambient air. Concerns have been raised over their potential human health impact in situations of inadvertent exposure. Oxidative mechanisms… read more here.
Keywords: bleomycin induced; fibrotic events; bleomycin; vivo vitro ... See more keywords
Benefit of Intracystic Bleomycin for Symptomatic Recurrent Rathke Cleft Cyst.
Sign Up to like & getrecommendations! Published in 2018 at "Operative neurosurgery"
DOI: 10.1093/ons/opy361
Abstract: BACKGROUND Management of recurrent Rathke cleft cysts (RCC) is problematic. The mainstay of treatment has been reoperation with cyst drainage. Radical cyst resection, although effective, results in a high incidence of diabetes insipidus. Several case… read more here.
Keywords: recurrent rcc; rathke cleft; bleomycin; intracystic bleomycin ... See more keywords
The effectiveness of long Pulsed Nd:YAG Laser alone for treatment of keloids and hypertrophic scars versus its combination with bleomycin.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cosmetic dermatology"
DOI: 10.1111/jocd.14509
Abstract: BACKGROUND AND OBJECTIVES Pathological scars are benign hyper-proliferative growths of dermal collagen that causes severe psychological and physical problems. This study was performed to assess and compare safety and clinical efficiency of combined pulsed Nd-YAG… read more here.
Keywords: pulsed yag; hypertrophic scars; bleomycin; treatment ... See more keywords
Cutaneous hyperpigmentation following bleomycin sclerotherapy for vascular malformations
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Dermatology"
DOI: 10.1111/pde.14869
Abstract: Systemic bleomycin therapy is associated with pulmonary fibrosis and cutaneous side effects. While it is believed that there is little to no systemic distribution of bleomycin when utilized to treat vascular malformations (VMs), we present… read more here.
Keywords: cutaneous hyperpigmentation; vascular malformations; hyperpigmentation following; bleomycin ... See more keywords