The Structure‐Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200186
Abstract: Human bleomycin hydrolase (hBH) catalyzes deamidation of the anticancer drug bleomycins (BLM). This enzyme is involved in BLM detoxification and drug resistance. Herein, we report the putative BLM‐binding site and catalytic mechanism of hBH. The… read more here.
Keywords: protease; cysteine protease; serine protease; bleomycin hydrolase ... See more keywords
Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c20479
Abstract: Bleomycins (BLMs) are widely used in clinics as antitumor agents. However, BLM-based chemotherapies often accompany severe pulmonary fibrosis (PF). Human bleomycin hydrolase is a cysteine protease that can convert BLMs into inactive deamido-BLMs. In this… read more here.
Keywords: mannose modified; bleomycin hydrolase; pulmonary fibrosis; bleomycin ... See more keywords