Agrimophol suppresses RANKL-mediated osteoclastogenesis through Blimp1-Bcl6 axis and prevents inflammatory bone loss in mice.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107137
Abstract: Excessive activity of osteoclasts causes many bone-related diseases, such as rheumatoid arthritis and osteoporosis. Agrimophol (AGR), a phenolic compound, originated from Agrimonia pilosa Ledeb. In prior studies, AGR is reported to possess schistosomicidal and mycobactericidal… read more here.
Keywords: agrimophol; osteoclastogenesis; blimp1; bone loss ... See more keywords
The BLIMP1—EZH2 nexus in a non-Hodgkin lymphoma
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DOI: 10.1038/s41388-020-1347-8
Abstract: Waldenström’s macroglobulinemia (WM) is a non-Hodgkin lymphoma, resulting in antibody-secreting lymphoplasmacytic cells in the bone marrow and pathologies resulting from high levels of monoclonal immunoglobulin M (IgM) in the blood. Despite the key role for… read more here.
Keywords: hodgkin lymphoma; blimp1 ezh2; non hodgkin; blimp1 ... See more keywords
Abstract 2702: Contribution of effector regulatory T cells to the regulation of antitumor immunity
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2702
Abstract: Regulatory T cells (Treg) belonging to the FoxP3 lineage stringently control immune responses and self-tolerance. Follicular regulatory T (TFR) cells, an effector Treg (eTreg) subset, not only suppress cellular responses but also regulate the magnitude… read more here.
Keywords: antitumor immunity; effector; blimp1; etreg ... See more keywords
BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer.
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DOI: 10.1158/2159-8290.cd-17-0250
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most metastatic and deadly cancers. Despite the clinical significance of metastatic spread, our understanding of molecular mechanisms that drive PDAC metastatic ability remains limited. By generating a… read more here.
Keywords: induces transient; metastatic ability; blimp1; blimp1 induces ... See more keywords
Combinatorial regulation of a Blimp1 (Prdm1) enhancer in the mouse retina
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DOI: 10.1371/journal.pone.0176905
Abstract: The mouse retina comprises seven major cell types that exist in differing proportions. They are generated from multipotent progenitors in a stochastic manner, such that the relative frequency of any given type generated changes over… read more here.
Keywords: blimp1 prdm1; blimp1; enhancer; mouse retina ... See more keywords
Pax5 Negatively Regulates Osteoclastogenesis through Downregulation of Blimp1
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DOI: 10.3390/ijms22042097
Abstract: Paired box protein 5 (Pax5) is a crucial transcription factor responsible for B-cell lineage specification and commitment. In this study, we identified a negative role of Pax5 in osteoclastogenesis. The expression of Pax5 was time-dependently… read more here.
Keywords: lineage; pax5; bone; blimp1 ... See more keywords
Downregulation of Blimp1 inhibits the maturation of bone marrow-derived dendritic cells.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2018.4000
Abstract: Modulation of differentiation of dendritic cells (DCs), which are derived from bone marrow cells, may influence their maturation and consequently regulate their ability to present antigens to alloreactive T lymphocytes. B lymphocyte‑induced maturation protein‑1 (Blimp1)… read more here.
Keywords: lenti shrna; shrna blimp1; blimp1; bone marrow ... See more keywords