Blinded sample size re‐estimation for comparing over‐dispersed count data incorporating follow‐up lengths
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9584
Abstract: Blinded sample size re‐estimation (BSSR) is an adaptive design to prevent the power reduction caused by misspecifications of the nuisance parameters in the sample size calculation of comparative clinical trials. However, conventional BSSR methods used… read more here.
Keywords: sample size; blinded sample; count data; size ... See more keywords
Blinded sample size re-estimation in a crossover study.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2025.2575947
Abstract: Bioequivalence studies play a pivotal role in drug development by establishing the clinical equivalence of two drug formulations. These studies often utilize crossover designs to facilitate within-subject treatment comparisons, optimizing statistical power with fewer subjects.… read more here.
Keywords: crossover; sample size; blinded sample; size ... See more keywords