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   Articles with "blm" as a keyword



Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats.

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recommendations! Published in 2023 at "Environmental toxicology"

DOI: 10.1002/tox.23824

Abstract: The effect of pachymic acid (PA) on pulmonary fibrosis in rats was expected to be investigated in this study. Firstly, bleomycin (BLM) was used to establish pulmonary fibrosis rat model, then PA (10, 20, or… read more here.

Keywords: lung tissue; blm; pulmonary fibrosis; induced pulmonary ... See more keywords

Brain linear measurement index in the differential diagnosis between idiopathic normal pressure hydrocephalus and progressive supranuclear palsy

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recommendations! Published in 2025 at "Neurological Sciences"

DOI: 10.1007/s10072-025-08478-z

Abstract: Differential diagnosis between idiopathic normal pressure hydrocephalus (iNPH) and progressive supranuclear palsy (PSP) could be challenging, due to the presence of similar clinical and neuroradiological features. Aim of this retrospective study was to differentiate iNPH… read more here.

Keywords: differential diagnosis; blm; inph psp; index ... See more keywords

An improved biotic ligand model (BLM) for predicting Co(II)-toxicity to wheat root elongation: The influences of toxic metal speciation and accompanying ions.

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recommendations! Published in 2019 at "Ecotoxicology and environmental safety"

DOI: 10.1016/j.ecoenv.2019.109433

Abstract: In order to explore the effects of pH and accompanying ions on divalent cobalt (Co(II)) toxicity to the wheat root elongation, an improved biotic ligand model (BLM) to predict Co(II) toxicity was developed in solution… read more here.

Keywords: toxicity; blm; wheat root; root elongation ... See more keywords

BLM can regulate cataract progression by influencing cell vitality and apoptosis

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recommendations! Published in 2019 at "Experimental Eye Research"

DOI: 10.1016/j.exer.2018.08.022

Abstract: ABSTRACT Age‐related cataract (ARC) is the most common cause of severe visual impairment and blindness. The precise mechanisms of ARC are not completely understood, but it is well accepted that oxidative damage plays an important… read more here.

Keywords: cell vitality; blm; progression; vitality apoptosis ... See more keywords

Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin‐induced pulmonary fibrosis by inhibiting TGF‐&bgr;1/Smad2 pathways and overexpression of NOX4

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recommendations! Published in 2017 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.04.024

Abstract: Abstract Pulmonary fibrosis, a progressive and lethal lung disease, is a major therapeutic challenge for which new therapeutic strategies are warranted. Schisandrin B (Sch B) and Glycyrrhizic acid (GA) are the principal active ingredients of… read more here.

Keywords: induced pulmonary; pulmonary fibrosis; blm; tgf bgr ... See more keywords

Structural Insight into BLM Recognition by TopBP1.

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recommendations! Published in 2017 at "Structure"

DOI: 10.1016/j.str.2017.08.005

Abstract: Topoisomerase IIβ binding protein 1 (TopBP1) is a critical protein-protein interaction hub in DNA replication checkpoint control. It was proposed that TopBP1 BRCT5 interacts with Bloom syndrome helicase (BLM) to regulate genome stability through either… read more here.

Keywords: structural insight; blm recognition; brct5; recognition topbp1 ... See more keywords

Amphiphile-Mediated Ultrasmall Aggregation Induced Emission Dots for Ultrasensitive Fluorescence Biosensing.

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recommendations! Published in 2017 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.7b01797

Abstract: The development of ultrasensitive and highly selective fluorescence biosensors for diverse analytes is highly desirable but remains a challenge. It is attributable to the scarcity of fluorogens with promising brightness, stability, and nontoxicity, which primarily… read more here.

Keywords: fluorescence; aggregation induced; ultrasensitive fluorescence; blm ... See more keywords

Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex

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recommendations! Published in 2022 at "Nature Communications"

DOI: 10.1038/s41467-022-28082-5

Abstract: Topoisomerase IIIα is a type 1A topoisomerase that forms a complex with RMI1 and RMI2 called TRR in human cells. TRR plays an essential role in resolving DNA replication and recombination intermediates, often alongside the… read more here.

Keywords: gate; blm; trr; stranded dna ... See more keywords

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-025-62966-6

Abstract: The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves various DNA replication and recombination intermediates to suppress genome instability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation. Both BLM and PICH undergo… read more here.

Keywords: protection; centromere protection; requires strict; protection requires ... See more keywords

Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-17007-8

Abstract: The potential role of macrophages in pulmonary fibrosis (PF) prompted us to evaluate the roles of CX3CR1, a chemokine receptor abundantly expressed in macrophages during bleomycin (BLM)-induced PF. Intratracheal BLM injection induced infiltration of leukocytes… read more here.

Keywords: fibrosis; cx3cr1; essential involvement; involvement cx3cl1 ... See more keywords

Functional conservation of RecQ helicase BLM between humans and Drosophila melanogaster

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-54101-5

Abstract: RecQ helicases are a family of proteins involved in maintaining genome integrity with functions in DNA repair, recombination, and replication. The human RecQ helicase family consists of five helicases: BLM, WRN, RECQL, RECQL4, and RECQL5.… read more here.

Keywords: functional conservation; recq helicase; drosophila melanogaster; recq ... See more keywords