Proteasome activator Blm10 regulates transcription especially during aging
Sign Up to like & getrecommendations! Published in 2021 at "Current Genomics"
DOI: 10.2174/1389202922666210601094643
Abstract: Histones are basic elements of the chromatin, and are critical to controlling chromatin structure and transcription. The proteasome activator PA200 promotes the acetylation-dependent proteasomal degradation of the core histones during spermatogenesis, DNA repair, transcription and… read more here.
Keywords: degradation; transcription; blm10; core histones ... See more keywords
Peptidomimetics Based on C-Terminus of Blm10 Stimulate Human 20S Proteasome Activity and Promote Degradation of Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12060777
Abstract: Degradation of misfolded, redundant and oxidatively damaged proteins constitutes one of the cellular processes which are influenced by the 20S proteasome. However, its activity is generally thought to decrease with age which leads to the… read more here.
Keywords: 20s proteasome; blm10; peptidomimetics based; activity ... See more keywords