Selective block of adenosine A2A receptors prevents ischaemic‐like effects induced by oxygen and glucose deprivation in rat medium spiny neurons
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DOI: 10.1111/bph.15922
Abstract: Ischaemia is known to cause massive neuronal depolarization, termed anoxic depolarization (AD), due to energy failure and loss of membrane ion gradients. The neuromodulator adenosine accumulates extracellularly during ischaemia and activates four metabotropic receptors: A1,… read more here.
Keywords: a2a receptors; block adenosine; spiny neurons; medium spiny ... See more keywords