Abstract 4645: Identification of conditionally active antibodies that selectively block CD39 activity in the acidic tumor microenvironment
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DOI: 10.1158/1538-7445.am2023-4645
Abstract: Background CD39 expression is upregulated in the tumor microenvironment (TME), which is characterized by high levels of extracellular ATP (eATP) and low pH. CD39 catalyzes the rate-limiting degradation step of this immunostimulatory ATP, leading to… read more here.
Keywords: cd39; inhibition; cd39 activity; activity ... See more keywords