CD47 Blockade and Cowpea Mosaic Virus Nanoparticle In Situ Vaccination Triggers Phagocytosis and Tumor Killing.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801288
Abstract: Contemporary immunotherapies, e.g., those that target the CTLA-4 and PD-1/PD-L1 axis, act on T cells to reinstate their antitumor activity. An alternative, and possibly more powerful approach is to target and reprogram the innate immune… read more here.
Keywords: cd47; blockade; cd47 blockade; situ vaccination ... See more keywords
Meta‐analysis of α‐blockade versus no blockade before adrenalectomy for phaeochromocytoma
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Surgery"
DOI: 10.1002/bjs.11348
Abstract: Preoperative α‐blockade in phaeochromocytoma surgery is recommended by all guidelines to prevent intraoperative cardiocirculatory events. The aim of this meta‐analysis was to assess the benefit of such preoperative treatment compared with no treatment before adrenalectomy… read more here.
Keywords: adrenalectomy phaeochromocytoma; blockade; meta analysis;
Nano-Econazole Enhanced PD-L1 Checkpoint Blockade for Synergistic Antitumor Immunotherapy against Pancreatic Ductal Adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207201
Abstract: Insufficienct T lymphocyte infiltration and unresponsiveness to immune checkpoint blockade therapy are still major difficulties for the clinical treatment of pancreatic ductal adenocarcinoma (PDAC). Although econazole has shown promise in inhibiting PDAC growth, its poor… read more here.
Keywords: antitumor; therapy; blockade; pdac ... See more keywords
[Residual neuromuscular blockade].
Sign Up to like & getrecommendations! Published in 2017 at "Der Anaesthesist"
DOI: 10.1007/s00101-017-0325-1
Abstract: Even small degrees of residual neuromuscular blockade, i. e. a train-of-four (TOF) ratio >0.6, may lead to clinically relevant consequences for the patient. Especially upper airway integrity and the ability to swallow may still be markedly impaired.… read more here.
Keywords: residual neuromuscular; neuromuscular blockade; blockade;
Progress of CD47 immune checkpoint blockade agents in anticancer therapy: a hematotoxic perspective
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03815-z
Abstract: CD47, a transmembrane protein, acts as a “do not eat me” signal that is overexpressed in many tumor cell types, thereby forming a signaling axis with its ligand signal regulatory protein alpha (SIRPα) and enabling… read more here.
Keywords: cd47 targeting; cd47; blockade; targeting agents ... See more keywords
Can therapeutic response to IL-1 blockade confirm the diagnosis of Schnitzler syndrome?
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Rheumatology"
DOI: 10.1007/s10067-020-05565-8
Abstract: To the editor I read with great interest the article by Bixio et al. [1] describing a 21-year-old female with clinically suspected Schnitzler syndrome but without detectable monoclonal gammopathy. In view of her favorable therapeutic… read more here.
Keywords: schnitzler; monoclonal gammopathy; blockade; schnitzler syndrome ... See more keywords
Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4884-x
Abstract: BackgroundA perennial challenge in systemic cytotoxic cancer therapy is to eradicate primary tumors and metastatic disease while sparing normal tissue from off-target effects of chemotherapy. Anthracyclines such as doxorubicin are effective chemotherapeutic agents for which… read more here.
Keywords: cd47; blockade; breast cancer; cancer ... See more keywords
Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02275-9
Abstract: Angelman syndrome (AS) is a neurogenetic disorder involving ataxia and motor dysfunction, resulting from the absence of the maternally inherited functional Ube3a protein in neurons. Since adenosine A2A receptor (A2AR) blockade relieves synaptic and motor… read more here.
Keywords: adenosine a2a; a2a receptor; blockade; angelman syndrome ... See more keywords
Cancer-cell-biomimetic nanoparticles systemically eliminate hypoxia tumors by synergistic chemotherapy and checkpoint blockade immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.10.010
Abstract: Abstract Checkpoint blockade-based immunotherapy has shown unprecedented effect in cancer treatments, but its clinical implementation has been restricted by the low host antitumor response rate. Recently, chemotherapy is well recognized to activate the immune system… read more here.
Keywords: blockade; cancer cell; checkpoint blockade; cancer ... See more keywords
IL-6 and PD-L1 blockade combination inhibits hepatocellular carcinoma cancer development in mouse model.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.128
Abstract: Limited efficacy of immune checkpoint inhibitors in hepatocellular carcinoma (HCC) was observed in clinical trials, thus prompting investigation into combination therapy. Interleukin-6 (IL-6) has important roles in modeling immune responses in cancers. Here, we hypothesized… read more here.
Keywords: hepatocellular carcinoma; combination; hcc; blockade ... See more keywords
A novel bispecific nanobody with PD-L1/TIGIT dual immune checkpoint blockade.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.072
Abstract: Cancer immunotherapy have changed the paradigm of cancer treatment, but there remains a great need for improvement given that less patients with tumors respond to the treatment of PD-1/PD-L1 blockade. TIGIT (also called T cell… read more here.
Keywords: immune checkpoint; tigit; blockade; cell ... See more keywords