IL-6 inhibition prevents costimulation blockade-resistant allograft rejection in T cell-depleted recipients by promoting intragraft immune regulation in mice
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DOI: 10.1038/s41467-024-48574-w
Abstract: The efficacy of costimulation blockade with CTLA4-Ig (belatacept) in transplantation is limited due to T cell-mediated rejection, which also persists after induction with anti-thymocyte globulin (ATG). Here, we investigate why ATG fails to prevent costimulation… read more here.
Keywords: blockade resistant; blockade; rejection; costimulation blockade ... See more keywords