Versatile Polymer‐Initiating Biomineralization for Tumor Blockade Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202110094
Abstract: Tumor blockade therapy is a promising penetration‐independent antitumor modality, which effectively inhibits the exchange of nutrients, oxygen, and information between the tumor and surrounding microenvironments. However, the current blockade therapy strategies have limited antitumor efficacy… read more here.
Keywords: tumor blockade; polymer; blockade therapy; biomineralization ... See more keywords
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.08.005
Abstract: We analyze the transcriptome of baseline and on-therapy tumor biopsies from 101 patients with advanced melanoma treated with nivolumab (anti-PD-1) alone or combined with ipilimumab (anti-CTLA-4). We find that T cell infiltration and interferon-γ (IFN-γ) signaling… read more here.
Keywords: checkpoint blockade; immune checkpoint; blockade therapy; response ... See more keywords
High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.9b03466
Abstract: Cancer photodynamic therapy (PDT) represents an attractive local treatment in combination with immunotherapy. Successful cancer PDT relies on the image-guidance to ensure the treatment accuracy. However, existing nanotechnology for co-delivery of photosensitizers and image contrast… read more here.
Keywords: blockade therapy; image; fluorescence image; cancer ... See more keywords
Synchronizing the Use of Allogeneic HCT in the Era of Checkpoint Blockade Therapy in the Management of Hodgkin Lymphoma.
Sign Up to like & getrecommendations! Published in 2021 at "Expert review of hematology"
DOI: 10.1080/17474086.2021.1965874
Abstract: INTRODUCTION The use of checkpoint blockade therapy (CBT) has shown impressive results for the treatment of relapsed/refractory Hodgkin lymphoma (cHL). The impact of CBT depends on the reversal of an exhausted T-cell immune phenotype and… read more here.
Keywords: checkpoint blockade; blockade therapy; use; hodgkin lymphoma ... See more keywords
Programmed cell death‐1 blockade therapy in melanoma: Resistance mechanisms and combination strategies
Sign Up to like & getrecommendations! Published in 2023 at "Experimental Dermatology"
DOI: 10.1111/exd.14750
Abstract: Melanoma is a highly aggressive tumor derived from melanocytes. In recent years, the incidence and mortality of melanoma have gradually increased, seriously threatening human health. Classic treatments like surgery, chemotherapy, and radiotherapy show very limited… read more here.
Keywords: melanoma; therapy; death; blockade therapy ... See more keywords
Impact of CD4 T cells on intratumoral CD8 T-cell exhaustion and responsiveness to PD-1 blockade therapy in mouse brain tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005293
Abstract: Background Glioblastoma is a fatal disease despite aggressive multimodal therapy. PD-1 blockade, a therapy that reinvigorates hypofunctional exhausted CD8 T cells (Tex) in many malignancies, has not shown efficacy in glioblastoma. Loss of CD4 T… read more here.
Keywords: cell; cd4 cells; cd4; blockade therapy ... See more keywords
Abstract 5283: Polyamine blockade therapy: A strategy to block immunosuppression in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5283
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients and is characterized by a dense tumor microenvironment (TME) which impedes tumor entry of immune cells and delivery of therapeutics. Immunosuppressive myeloid populations of PDAC,… read more here.
Keywords: cancer; polyamine blockade; tumor; immunosuppression ... See more keywords
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-18-0367
Abstract: Immune checkpoint blockade is able to induce durable responses across multiple types of cancer, which has enabled the oncology community to begin to envision potentially curative therapeutic approaches. However, the remarkable responses to immunotherapies are… read more here.
Keywords: checkpoint blockade; immune checkpoint; blockade therapy; checkpoint ... See more keywords
Modulation of Gut Microbiota: A Novel Paradigm of Enhancing the Efficacy of Programmed Death-1 and Programmed Death Ligand-1 Blockade Therapy
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00374
Abstract: Blockade of programmed death 1 (PD-1) protein and its ligand programmed death ligand 1 (PD-L1) has been used as cancer immunotherapy in recent years, with the blockade of PD-1 being more widely used than blockade… read more here.
Keywords: programmed death; blockade; blockade therapy; gut microbiota ... See more keywords
Wnt Inhibition Sensitizes PD-L1 Blockade Therapy by Overcoming Bone Marrow-Derived Myofibroblasts-Mediated Immune Resistance in Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.619209
Abstract: Cancer-associated fibroblasts (CAFs) has been recognized as one cause of tumor resistance to immune checkpoint blockade therapy, but the underlying mechanisms still remain elusive. In the present study, a bone marrow-derived CAF (BMF) -rich tumor… read more here.
Keywords: blockade therapy; marrow derived; tumor; resistance ... See more keywords
Exosomal PD-L1 detection in cancer predictive biomarker for response to immune checkpoint blockade therapy
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1603855
Abstract: Programmed death-ligand 1 (PD-L1) carried by tumor-derived exosomes has emerged as a critical mediator of immune evasion and resistance to immune checkpoint blockade therapy. Unlike membrane-bound PD-L1, exosomal PD-L1 is systemically distributed and capable of… read more here.
Keywords: immune checkpoint; blockade therapy; checkpoint blockade;