Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers
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DOI: 10.1097/aln.0000000000002157
Abstract: Background: CW002 is an investigational nondepolarizing, neuromuscular blocking agent with a rapid onset and intermediate duration of action in animals. This is a single ascending dose, healthy subject study exploring tolerability, pharmacokinetics, and potency. Methods:… read more here.
Keywords: blocking agent; neuromuscular blocking; model; cw002 investigational ... See more keywords
Neuromuscular blocking agent induced hypersensitivity reaction exploration: an update
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DOI: 10.1097/eja.0000000000001765
Abstract: Acute hypersensitivity reactions (AHRs) occurring in present-day anaesthesia can have severe, sometimes fatal, consequences and their incidence is increasing. The most frequent allergens responsible for AHR during anaesthesia are neuromuscular blocking agents (NMBAs) (70% of… read more here.
Keywords: agent induced; blocking agent; neuromuscular blocking; anaesthetic procedures ... See more keywords
Supramolecular therapeutics to treat the side effects induced by a depolarizing neuromuscular blocking agent
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DOI: 10.7150/thno.34947
Abstract: Succinylcholine (Sch) is the only depolarizing neuromuscular blocking agent widely used for rapid sequence induction in emergency rooms. Unfortunately, a variety of (sometimes lethal) adverse effects, such as hyperkalemia and cardiac arrest, are associated with… read more here.
Keywords: blocking agent; neuromuscular blocking; depolarizing neuromuscular; treat side ... See more keywords