Blockade of PD-1 and TIM-3 immune checkpoints fails to restore the function of exhausted CD8+ T cells in early clinical stages of chronic lymphocytic leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Immunologic research"
DOI: 10.1007/s12026-020-09146-4
Abstract: Blocking antibodies targeting immune checkpoint molecules achieved invaluable success in tumor therapy and amazing clinical responses in a variety of cancers. Although common treatment protocols have improved overall survival in patients with chronic lymphocytic leukemia… read more here.
Keywords: lymphocytic leukemia; blocking antibodies; cd8 cells; chronic lymphocytic ... See more keywords
Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.091
Abstract: Immune checkpoint inhibitors have revolutionized cancer treatment. However, many cancers are resistant to ICIs, and the targeting of additional inhibitory signals is crucial for limiting tumor evasion. The production of adenosine via the sequential activity… read more here.
Keywords: cancer; combination; cd39 cd73; blocking antibodies ... See more keywords
A mouse pancreatic organoid model to compare PD-L1 blocking antibodies
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2139886
Abstract: ABSTRACT Immune checkpoint inhibitors (ICIs) have changed the therapeutic landscape for cancer patients, but diabetes, a rare, severe immune-related endocrinopathy, is linked to ICI therapy. It is unclear whether glycosylation of ICIs may play a… read more here.
Keywords: blocking antibodies; pancreatic organoid; mouse pancreatic; organoid model ... See more keywords
O01.5 A meningococcal native outer membrane vesicle vaccine as a platform for presenting conserved gonococcal antigens
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2019-sti.108
Abstract: Background Neisseria meningitidis (Nm) outer membrane vesicles (OMV) are treated with detergents to decrease endotoxin activity, which removes lipoproteins and may result in non-native protein structures. Previously, we prepared native OMV (NOMV) vaccines from mutant… read more here.
Keywords: vaccine; nomv fhbp; outer membrane; blocking antibodies ... See more keywords