Selection of a PD‐1 blocking antibody from a novel fully human phage display library
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4486
Abstract: Programmed cell death protein 1 (PD‐1) is an immunoregulatory target which is recognized by different monoclonal antibodies, approved for the therapy of multiple types of cancer. Different anti‐PD‐1 antibodies display different therapeutic properties and there… read more here.
Keywords: selection blocking; blocking antibody; phage display; antibody ... See more keywords
CD47 blocking antibody accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105384
Abstract: Background CD47, a glycoprotein on red blood cell membranes, inhibits phagocytosis via interaction with signal regulatory protein α on phagocytes. Our previous research has demonstrated that blocking CD47 accelerates hematoma clearance and reduces brain injury… read more here.
Keywords: cd47 blocking; cd47; blocking antibody; hematoma clearance ... See more keywords
Abstract LB220: S095029: a novel clinical-stage Fc-silenced NKG2A-blocking antibody with best-in-class potential
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb220
Abstract: NKG2A and its ligand HLA-E are increasingly recognized as an important immune checkpoint restraining multiple lymphocyte populations involved in cancer immunity. Initially described as an NK cell inhibitory receptor, NKG2A’s role in regulating T-cell functions… read more here.
Keywords: nkg2a blocking; blocking antibody; s095029; clinical stage ... See more keywords
Response by Hua et al to Letter Regarding Article, "Enhancement of Hematoma Clearance With CD47 Blocking Antibody in Experimental Intracerebral Hemorrhage".
Sign Up to like & getrecommendations! Published in 2019 at "Stroke"
DOI: 10.1161/strokeaha.119.026620
Abstract: In Response: We thank Dr Chen et al for their interest in our article. We have demonstrated that CD47 blocking antibody can enhance hematoma clearance through activation of microglia/macrophages and improve functional outcomes in a… read more here.
Keywords: blocking antibody; cd47; antibody; hematoma clearance ... See more keywords
Preclinical validation of a novel metastasis‐inhibiting Tie1 function‐blocking antibody
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201911164
Abstract: The angiopoietin (Ang)–Tie pathway has been intensely pursued as candidate second‐generation anti‐angiogenic target. While much of the translational work has focused on the ligand Ang2, the clinical efficacy of Ang2‐targeting drugs is limited and failed… read more here.
Keywords: function blocking; metastasis; tie1; tie1 function ... See more keywords
Pfs230 and Pfs48/45 Fusion Proteins Elicit Strong Transmission-Blocking Antibody Responses Against Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01256
Abstract: The Plasmodium falciparum Pfs230 and Pfs48/45 proteins are expressed during transmission from man to mosquito and are leading candidates for a malaria transmission blocking vaccine. Individually they generate transmission blocking (TB) antibodies in rodent models.… read more here.
Keywords: pfs230 pfs48; transmission; plasmodium falciparum; transmission blocking ... See more keywords
TRPM4 Blocking Antibody Protects Cerebral Vasculature in Delayed Stroke Reperfusion
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051480
Abstract: Reperfusion therapy for acute ischemic stroke aims to restore the blood flow of occluded blood vessels. However, successful recanalization is often associated with disruption of the blood-brain barrier, leading to reperfusion injury. Delayed recanalization increases… read more here.
Keywords: stroke reperfusion; blocking antibody; reperfusion; trpm4 blocking ... See more keywords