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Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4486
Abstract: Programmed cell death protein 1 (PD‐1) is an immunoregulatory target which is recognized by different monoclonal antibodies, approved for the therapy of multiple types of cancer. Different anti‐PD‐1 antibodies display different therapeutic properties and there…
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Keywords:
selection blocking;
blocking antibody;
phage display;
antibody ... See more keywords
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0
Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105384
Abstract: Background CD47, a glycoprotein on red blood cell membranes, inhibits phagocytosis via interaction with signal regulatory protein α on phagocytes. Our previous research has demonstrated that blocking CD47 accelerates hematoma clearance and reduces brain injury…
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Keywords:
cd47 blocking;
cd47;
blocking antibody;
hematoma clearance ... See more keywords
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2
Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb220
Abstract: NKG2A and its ligand HLA-E are increasingly recognized as an important immune checkpoint restraining multiple lymphocyte populations involved in cancer immunity. Initially described as an NK cell inhibitory receptor, NKG2A’s role in regulating T-cell functions…
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Keywords:
nkg2a blocking;
blocking antibody;
s095029;
clinical stage ... See more keywords
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1
Published in 2019 at "Stroke"
DOI: 10.1161/strokeaha.119.026620
Abstract: In Response: We thank Dr Chen et al for their interest in our article. We have demonstrated that CD47 blocking antibody can enhance hematoma clearance through activation of microglia/macrophages and improve functional outcomes in a…
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Keywords:
blocking antibody;
cd47;
antibody;
hematoma clearance ... See more keywords
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Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201911164
Abstract: The angiopoietin (Ang)–Tie pathway has been intensely pursued as candidate second‐generation anti‐angiogenic target. While much of the translational work has focused on the ligand Ang2, the clinical efficacy of Ang2‐targeting drugs is limited and failed…
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Keywords:
function blocking;
metastasis;
tie1;
tie1 function ... See more keywords
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1
Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01256
Abstract: The Plasmodium falciparum Pfs230 and Pfs48/45 proteins are expressed during transmission from man to mosquito and are leading candidates for a malaria transmission blocking vaccine. Individually they generate transmission blocking (TB) antibodies in rodent models.…
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Keywords:
pfs230 pfs48;
transmission;
plasmodium falciparum;
transmission blocking ... See more keywords
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2
Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051480
Abstract: Reperfusion therapy for acute ischemic stroke aims to restore the blood flow of occluded blood vessels. However, successful recanalization is often associated with disruption of the blood-brain barrier, leading to reperfusion injury. Delayed recanalization increases…
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Keywords:
stroke reperfusion;
blocking antibody;
reperfusion;
trpm4 blocking ... See more keywords