Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15905
Abstract: HERG blocking drugs known for their propensity to trigger Torsades de Pointes (TdP) were reported to induce a sympatho‐vagal coactivation and to enhance High Frequency heart rate (HFHR) and QT oscillations (HFQT) in telemetric data.… read more here.
Keywords: blocking drugs; haemodynamic side; herg blocking; side effects ... See more keywords
Natural Products: A Potential Source of Malaria Transmission Blocking Drugs?
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13090251
Abstract: The ability to block human-to-mosquito and mosquito-to-human transmission of Plasmodium parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a transmission-blocking drug but its use is… read more here.
Keywords: potential source; transmission; natural products; blocking drugs ... See more keywords
Critical examination of approaches exploited to assess the effectiveness of transmission-blocking drugs for malaria.
Sign Up to like & getrecommendations! Published in 2018 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0169
Abstract: In the absence of clinically proven vaccines and emerging resistance to common antimalarials and insecticides, the onus of interrupting the life cycle of Plasmodium falciparum, is upon the transmission-blocking drugs. Current transmission-blocking drug primaquine finds… read more here.
Keywords: transmission; examination approaches; approaches exploited; blocking drugs ... See more keywords