Disintegrin tablysin-15 suppresses cancer hallmarks in melanoma cells by blocking FAK/Akt/ERK and NF-κB signaling.
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DOI: 10.2174/1568009620666200101094736
Abstract: BACKGROUND Integrinsarecrucial anti-cancer therapy targets. We previously showed that tablysin-15 is an integrin antagonist via its Arg-Gly-Asp motif in a novel structural context. OBJECTIVE Here we investigated the anti-cancer effectsand mechanisms of action of tablysin-15… read more here.
Keywords: blocking fak; akt erk; fak akt; melanoma cells ... See more keywords