Blocking the FKBP12 induced dendrimeric burst in aberrant aggregation of α-synuclein by using the ElteN378 synthetic inhibitor
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DOI: 10.1080/14756366.2019.1667342
Abstract: Abstract α-Synuclein (α-syn), a disordered cytoplasmatic protein, plays a fundamental role in the pathogenesis of Parkinson’s disease (PD). Here, we have shown, using photophysical measurements, that addition of FKBP12 to α-syn solutions, dramatically accelerates protein… read more here.
Keywords: blocking fkbp12; aggregation; synuclein; synthetic inhibitor ... See more keywords