Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives
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DOI: 10.1080/14756366.2018.1452919
Abstract: Abstract A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced ≥62% HSD1 inhibition… read more here.
Keywords: coumarin; synthesis pathways; inhibition; blocking oestradiol ... See more keywords