Articles with "blocking pde4b" as a keyword



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Application of automated machine learning in the identification of multi-target-directed ligands blocking PDE4B, PDE8A, and TRPA1 with potential use in the treatment of asthma and COPD.

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Published in 2023 at "Molecular informatics"

DOI: 10.1002/minf.202200214

Abstract: The aim of the study was to develop AutoML models to search for novel MTDL chemotypes blocking PDE4B, PDE8A, and TRPA1. Asthma and COPD are characterized by complex pathophysiology associated with chronic inflammation, bronchoconstriction, and… read more here.

Keywords: pde4b pde8a; asthma copd; blocking pde4b; pde4b ... See more keywords