Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01924-3
Abstract: The Plasmodium falciparum Pfs25 protein (Pfs25) is a leading malaria transmission-blocking vaccine antigen. Pfs25 vaccination is intended to elicit antibodies that inhibit parasite development when ingested by Anopheles mosquitoes during blood meals. The Pfs25 three-dimensional… read more here.
Keywords: blocking vaccine; malaria transmission; vaccine antigen; transmission blocking ... See more keywords
Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins
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DOI: 10.1038/s42003-020-01123-9
Abstract: Proteins Pfs230 and Pfs48/45 are Plasmodium falciparum transmission-blocking (TB) vaccine candidates that form a membrane-bound protein complex on gametes. The biological role of Pfs230 or the Pfs230-Pfs48/45 complex remains poorly understood. Here, we present the… read more here.
Keywords: pfs230; blocking vaccine; pfs230 pfs48; transmission blocking ... See more keywords
Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya
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DOI: 10.1371/journal.pone.0266394
Abstract: Background Leading transmission-blocking vaccine candidates such as Plasmodium falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may render them ineffective or allele-specific. This study examines the level of genetic diversity, signature of… read more here.
Keywords: pfs25 gene; blocking vaccine; transmission; transmission blocking ... See more keywords
Development and Qualification of an Antigen Integrity Assay for a Plasmodium falciparum Malaria Transmission Blocking Vaccine Candidate, Pfs230
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DOI: 10.3390/vaccines10101628
Abstract: During development of a subunit vaccine, monitoring integrity of the recombinant protein for process development and quality control is critical. Pfs230 is a leading malaria transmission blocking vaccine candidate and the first to reach a… read more here.
Keywords: blocking vaccine; development; pfs230; integrity ... See more keywords