AIFM2 blocks ferroptosis independent of ubiquinol metabolism.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.066
Abstract: Ferroptosis is a multi-step regulated cell death that is characterized by excessive iron accumulation and lipid peroxidation. Cancer cells can acquire resistance to ferroptosis by the upregulation of anti-ferroptotic proteins or by the downregulation of… read more here.
Keywords: aifm2; mechanism; blocks ferroptosis; aifm2 blocks ... See more keywords
FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107189119
Abstract: SignificanceThe current study reveals the functions of FAF1 in protecting cells from ferroptosis, a novel cell death pathway triggered by PUFA peroxidation. In the absence of FAF1, cultured cells and mice are extremely sensitive to… read more here.
Keywords: peroxidation; faf1; inhibiting peroxidation; ferroptosis inhibiting ... See more keywords