Copy number variations across the blood–brain barrier in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51573
Abstract: Multiple sclerosis (MS) is a neuroinflammatory disease where immune cells cross the blood–brain barrier (BBB) into the central nervous system (CNS). What predisposes these immune cells to cross the BBB is still unknown. Here, we… read more here.
Keywords: blood; blood brain; multiple sclerosis; brain barrier ... See more keywords
Engineering the Human Blood–Brain Barrier at the Capillary Scale using a Double‐Templating Technique
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202110289
Abstract: In vitro blood–brain barrier (BBB) models have played an important role in studying processes such as immune cell trafficking and drug delivery, as well as contributing to the understanding of mechanisms of disease progression. Many… read more here.
Keywords: capillary scale; brain barrier; blood brain; brain ... See more keywords
Protease Responsive Nanogels for Transcytosis across the Blood-Brain Barrier and Intracellular Delivery of Radiopharmaceuticals to Brain Tumor Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100812
Abstract: Despite profound advances in treatment approaches, gliomas remain associated with very poor prognoses. The residual cells after incomplete resection often migrate and proliferate giving a seed for highly resistant gliomas. The efficacy of chemotherapeutic drugs… read more here.
Keywords: blood brain; delivery; tumor cells; transcytosis ... See more keywords
NIR‐Assisted MgO‐Based Polydopamine Nanoparticles for Targeted Treatment of Parkinson's Disease through the Blood–Brain Barrier
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201655
Abstract: The blood–brain barrier (BBB) is a major limiting factor that prevents the treatment of Parkinson's disease (PD). In the present study, MgOp@PPLP nanoparticles are explored by using MgO nanoparticles as a substrate, polydopamine as a… read more here.
Keywords: mgop pplp; blood brain; brain barrier; brain ... See more keywords
Guiding Brain-Tumor Surgery via Blood-Brain-Barrier-Permeable Gold Nanoprobes with Acid-Triggered MRI/SERRS Signals.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced materials"
DOI: 10.1002/adma.201603917
Abstract: Surgical resection is a mainstay in the treatment of malignant brain tumors. Surgeons, however, face great challenges in distinguishing tumor margins due to their infiltrated nature. Here, a pair of gold nanoprobes that enter a… read more here.
Keywords: blood brain; gold nanoprobes; brain tumor; brain ... See more keywords
Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201801362
Abstract: Therapies directed toward the central nervous system remain difficult to translate into improved clinical outcomes. This is largely due to the blood-brain barrier (BBB), arguably the most tightly regulated interface in the human body, which… read more here.
Keywords: blood brain; brain; neurological diseases; brain barrier ... See more keywords
Maximum Emission Peak Over 1500 nm of Organic Assembly for Blood–Brain Barrier‐Crossing NIR‐IIb Phototheranostics of Orthotopic Glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202208097
Abstract: The development of blood–brain barrier (BBB)‐crossing phototheranostic agents in second near‐infrared window (NIR‐II), especially in the range of 1500–1700 nm (NIR‐IIb), affords great opportunities for glioblastoma (GBM) management. Herein, an organic assembly (denoted as LET‐12)… read more here.
Keywords: iib phototheranostics; blood brain; peak; nir iib ... See more keywords
3D In Vitro Blood‐Brain‐Barrier Model for Investigating Barrier Insults
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205752
Abstract: The blood-brain-barrier (BBB) prevents that harmful substances in the blood enter the brain, and barrier disruption has been associated with a variety of central-nervous-system diseases. In vitro BBB models enable to recapitulate the BBB behavior… read more here.
Keywords: blood brain; bbb; barrier; brain barrier ... See more keywords
Apremilast exerts protective effects on stroke outcomes and blood–brain barrier (BBB) dysfunction through regulating Rho‐associated protein kinase 2 expression
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2677
Abstract: Stroke is a devastating event and a huge public health concern worldwide. Apremilast (APR) is a selective inhibitor of phosphodiesterase‐4 involved in various neurological diseases, including stroke. However, the protective effects of APR on stroke… read more here.
Keywords: protective effects; blood brain; brain barrier; brain ... See more keywords
Indoloazepinone‐Constrained Oligomers as Cell‐Penetrating and Blood–Brain‐Barrier‐Permeating Compounds
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201700678
Abstract: Non‐cationic and amphipathic indoloazepinone‐constrained (Aia) oligomers have been synthesized as new vectors for intracellular delivery. The conformational preferences of the [l‐Aia‐Xxx]n oligomers were investigated by circular dichroism (CD) and NMR spectroscopy. Whereas Boc‐[l‐Aia‐Gly]2,4‐OBn oligomers 12… read more here.
Keywords: blood brain; aia; boc aia; indoloazepinone constrained ... See more keywords
Investigation of the Transporting Behavior of Framework DNA Nano‐Devices Across the Artificial Blood‐Brain Barrier (BBB)
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200459
Abstract: This study focused on exploring the ability of self‐assembled DNA frameworks to cross the blood‐brain barrier (BBB). We designed and assembled a series of DNA origami structures with equal quantity of nucleic acid materials but… read more here.
Keywords: blood brain; barrier bbb; brain barrier; dna ... See more keywords