Chemobrain in blood cancers: How chemotherapeutics interfere with the brain's structure and functionality, immune system, and metabolic functions.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21977
Abstract: Cancer treatment brings about a phenomenon not fully clarified yet, termed chemobrain. Its strong negative impact on patients' well-being makes it a trending topic in current research, interconnecting many disciplines from clinical oncology to neuroscience.… read more here.
Keywords: blood cancers; brain; blood; immune system ... See more keywords
TRIM proteins in blood cancers
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-017-0423-5
Abstract: Post-translational modification of proteins with ubiquitin plays a central role in regulating numerous cellular processes. E3 ligases determine the specificity of ubiquitination by mediating the transfer of ubiquitin to substrate proteins. The family of tripartite… read more here.
Keywords: trim proteins; blood cancers; proteins blood;
ALDHs in normal and malignant hematopoietic cells: Potential new avenues for treatment of AML and other blood cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.06.020
Abstract: Multiple studies have demonstrated that ALDH1A1 is elevated in hematopoietic stem cells (HSCs). As a means to better characterize such cells, we previously developed the fluorescent ALDH1A1 substrate Aldefluor to facilitate HSC identification and isolation.… read more here.
Keywords: aldhs normal; biology; blood; aml blood ... See more keywords
Integration of hypoxic HIF-α signaling in blood cancers
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DOI: 10.1038/onc.2017.119
Abstract: Hypoxia (low O2) is a fundamental microenvironmental determinant of bone marrow (BM) pathophysiology. Recent data from molecular and clinical studies indicate that hematopoiesis and leukemogenesis are dependent upon hypoxia-inducible factors (HIFs), a family of essential… read more here.
Keywords: hif signaling; integration hypoxic; hypoxic hif; blood ... See more keywords
Statins enhance efficacy of venetoclax in blood cancers
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaq1240
Abstract: Statins cooperate with proapoptotic drugs to enhance tumor killing in blood cancers. Yet another health benefit of statins Statins, common drugs used for the treatment of high cholesterol, may have found another potential application. In… read more here.
Keywords: statins enhance; blood; efficacy venetoclax; venetoclax blood ... See more keywords
Celgene Targets Blood Cancers with Major Buys.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2018-007
Abstract: Celgene acquired Juno Therapeutics for $9 billion and is spending up to $7 billion on Impact Biomedicines in an effort to diversify its hematology portfolio with chimeric antigen receptor T-cell therapies and a JAK2 inhibitor… read more here.
Keywords: hematology; celgene targets; targets blood; major buys ... See more keywords
Characteristics of Inpatients With Blood Cancers Who Experience a Fall: A Retrospective Study.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical journal of oncology nursing"
DOI: 10.1188/22.cjon.204-209
Abstract: BACKGROUND Inpatients with cancer are at the greatest risk for falling. Although studies have identified the characteristics of patients with cancer who fall, few studies have focused on the characteristics of patients with blood cancers… read more here.
Keywords: characteristics inpatients; fall; blood cancers; cancers experience ... See more keywords
Incurable but treatable: Understanding, uncertainty and impact in chronic blood cancers—A qualitative study from the UK’s Haematological Malignancy Research Network
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DOI: 10.1371/journal.pone.0263672
Abstract: Objective Most blood cancers are incurable and typically follow unpredictable remitting-relapsing pathways associated with varying need for treatment, which may be distressing for patients. Our objective was to conduct a qualitative study to explore understanding… read more here.
Keywords: blood cancers; uncertainty; malignancy; impact ... See more keywords
Vγ9Vδ2 T-cell immunotherapy in blood cancers: ready for prime time?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1167443
Abstract: In the last years, the tumor microenvironment (TME) has emerged as a promising target for therapeutic interventions in cancer. Cancer cells are highly dependent on the TME to growth and evade the immune system. Three… read more here.
Keywords: cell; blood cancers; immunotherapy blood; cell immunotherapy ... See more keywords
The “Vesicular Intelligence” Strategy of Blood Cancers
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DOI: 10.3390/genes12030416
Abstract: Blood cancers are a heterogeneous group of disorders including leukemia, multiple myeloma, and lymphoma. They may derive from the clonal evolution of the hemopoietic stem cell compartment or from the transformation of progenitors with immune… read more here.
Keywords: vesicular intelligence; intelligence strategy; strategy blood; blood ... See more keywords
Therapeutic Role of Carotenoids in Blood Cancer: Mechanistic Insights and Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14091949
Abstract: Blood cancers are characterized by pathological disorders causing uncontrolled hematological cell division. Various strategies were previously explored for the treatment of blood cancers, including chemotherapy, Car-T therapy, targeting chimeric antigen receptors, and platelets therapy. However,… read more here.
Keywords: blood cancers; therapeutic potential; blood cancer; cancer ... See more keywords