How CBX proteins regulate normal and leukemic blood cells
Sign Up to like & getrecommendations! Published in 2024 at "Febs Letters"
DOI: 10.1002/1873-3468.14839
Abstract: Hematopoietic stem cell (HSC) fate decisions are dictated by epigenetic landscapes. The Polycomb Repressive Complex 1 (PRC1) represses genes that induce differentiation, thereby maintaining HSC self‐renewal. Depending on which chromobox (CBX) protein (CBX2, CBX4, CBX6,… read more here.
Keywords: hsc; blood cells; leukemic blood; cbx proteins ... See more keywords
Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding
Sign Up to like & getrecommendations! Published in 2025 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.70005
Abstract: Red blood cells (RBCs) have emerged as reservoirs of microRNAs (miRNAs) in the circulatory system, challenging the traditional view of their nucleic acid absence. This study investigates the miRNA profiles and stability of both native… read more here.
Keywords: cells could; could protect; blood cells; red blood ... See more keywords
A Dynamic Membrane‐Active Glycopeptide for Enhanced Protection of Human Red Blood Cells against Freeze‐Stress
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202516
Abstract: Intracellular delivery of freezing‐tolerant trehalose is crucial for cryopreservation of red blood cells (RBCs) and previous strategies based on membrane‐disruptive activity usually generate severe hemolysis. Herein, a dynamic membrane‐active glycopeptide is developed by grafting with… read more here.
Keywords: dynamic membrane; glycopeptide; red blood; blood cells ... See more keywords
Converting Red Blood Cells to Efficient Microreactors for Blood Detoxification.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced materials"
DOI: 10.1002/adma.201603673
Abstract: A simple method to convert red blood cells (RBCs) into efficient microreactors is reported. Triton X-100 is employed at finely tuned concentrations to render RBCs highly permeable to substrates, while low concentrations of glutaraldehyde are… read more here.
Keywords: red blood; efficient microreactors; blood detoxification; blood ... See more keywords
Detecting Swelling States of Red Blood Cells by “Cell–Fluid Coupling Spectroscopy”
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Science"
DOI: 10.1002/advs.201600238
Abstract: Red blood cells are “shaken” with a holographic optical tweezer array. The flow generated around cells due to the periodic optical forcing is measured with an optically trapped “detector” particle located in the cell vicinity.… read more here.
Keywords: red blood; swelling states; spectroscopy; detecting swelling ... See more keywords
Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano‐Red Blood Cells
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201801678
Abstract: Abstract Morphologically discrete nanoarchitectures, which mimic the structural complexity of biological systems, are an increasingly popular design paradigm in the development of new nanomedical technologies. Herein, engineered polymeric stomatocytes are presented as a structural and… read more here.
Keywords: red blood; multifunctional polylactide; blood cells; biomorphic engineering ... See more keywords
Mature Red Blood Cells Contain Long DNA Fragments and Could Acquire DNA from Lung Cancer Tissue
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206361
Abstract: Red blood cells (RBC) are commonly known as cells with no nucleus or mitochondria and are assumed to be a transportation vehicle. This study confirms that RBC contain long DNA fragments inside with stain by… read more here.
Keywords: cell; dna; red blood; blood cells ... See more keywords
Centrifugation‐free washing: A novel approach for removing immunoglobulin A from stored red blood cells
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25026
Abstract: Washed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients. Centrifugation‐based cell processors commonly used by hospital blood banks cannot consistently reduce IgA below the recommended levels, hence double washing is frequently… read more here.
Keywords: red blood; washing system; centrifugation; blood ... See more keywords
Increased Phospho‐AKT in Blood Cells from LRRK2 G2019S Mutation Carriers
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26469
Abstract: The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). We assessed phospho(P)‐Ser‐935‐LRRK2 and P‐Ser‐473‐AKT levels in peripheral blood cells from patients… read more here.
Keywords: ser 473; blood cells; increased phospho; blood ... See more keywords
Stronger medical links for umbilical cord blood
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22024
Abstract: F or centuries, umbilical cord blood was considered medical waste and simply thrown away. However, within the last few years, researchers have dramatically expanded its repertoire of treatments and potential cures. After the umbilical cord… read more here.
Keywords: cord blood; umbilical cord; blood transplantations; blood ... See more keywords
Hemolysis of red blood cells in blood vessels modeled via computational fluid dynamics.
Sign Up to like & getrecommendations! Published in 2023 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3699
Abstract: The research aims to verify the universal relationship between vessel shape and the risk of hemolysis using a rheological model of blood reflecting the physiological processes related to blood for any blood vessel. Blood is… read more here.
Keywords: hemolysis; rheology; red blood; blood cells ... See more keywords