Targeting modulation of the choroid plexus blood-CSF barrier and CSF hypersecretion via lipid nanoparticle-mediated co-delivery of siRNA and resveratrol
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61543-1
Abstract: Hydrocephalus is one of the most common neurological disorders, but pharmacotherapy options are currently lacking due to the complex pathogenesis. The blood-CSF barrier (BCSFB), consisting of choroid plexus (ChP) epithelial cells, is a crucial gate… read more here.
Keywords: csf barrier; csf; blood csf; choroid plexus ... See more keywords
L-Arginine and asymmetric dimethylarginine (ADMA) transport across the mouse blood-brain and blood-CSF barriers: Evidence of saturable transport at both interfaces and CNS to blood efflux
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1101/2024.05.30.596616
Abstract: L-Arginine is the physiological substrate for the nitric oxide synthase (NOS) family, which synthesises nitric oxide (NO) in endothelial and neuronal cells. NO synthesis can be inhibited by endogenous asymmetric dimethylarginine (ADMA). NO has explicit… read more here.
Keywords: arginine; transport; blood csf; blood ... See more keywords
Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study
Sign Up to like & getrecommendations! Published in 2020 at "Fluids and Barriers of the CNS"
DOI: 10.1186/s12987-019-0163-4
Abstract: Both aging and changes in blood flow velocity between the extracranial (intraspinal) and intracranial regions of cerebral vessels have an impact on brain hydro-hemodynamics. Arterial and venous cerebral blood flows interact with cerebrospinal fluid (CSF)… read more here.
Keywords: blood flow; csf; blood; blood csf ... See more keywords
154 Elucidating the Immune Landscape of Radiation Necrosis Through Single Cell Analysis of Recurrent Brain Lesions in Patients After Stereotactic Radio Surgery
Sign Up to like & getrecommendations! Published in 2024 at "Neurosurgery"
DOI: 10.1227/neu.0000000000002809_154
Abstract: INTRODUCTION: Radiation necrosis (RN), a common and morbid side effect of radiosurgical treatment of brain metastasis, is becoming more prevalent as immunotherapy options and patient survival improve. Thought to be immunologically driven, the pathophysiology of… read more here.
Keywords: brain; radiation necrosis; single cell; blood csf ... See more keywords
Big data and artificial intelligence applied to blood and CSF fluid biomarkers in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1459502
Abstract: Artificial intelligence (AI) has meant a turning point in data analysis, allowing predictions of unseen outcomes with precedented levels of accuracy. In multiple sclerosis (MS), a chronic inflammatory-demyelinating condition of the central nervous system with… read more here.
Keywords: blood csf; multiple sclerosis; fluid biomarkers; artificial intelligence ... See more keywords