Airway epithelial type‐2 alarmin profiles: Blood eosinophil counts remain in memory
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250101
Abstract: Epithelial cytokines are involved in the orchestration of T1/T2 inflammatory patterns. We question the persistence of this trait in air–liquid interface (ALI) epithelial cultures and whether this local orientation can be related to systemic patterns… read more here.
Keywords: epithelial type; airway epithelial; blood eosinophil; alarmin ... See more keywords
Low and High Blood Eosinophil Counts as Biomarkers in Hospitalized Acute Exacerbations of COPD.
Sign Up to like & getrecommendations! Published in 2019 at "Chest"
DOI: 10.1016/j.chest.2019.02.406
Abstract: BACKGROUND Characterizing acute exacerbations of COPD (AECOPD) and individualizing therapy is challenging. Key exacerbation therapies include antibiotics and systemic corticosteroids. Blood eosinophils, when either low or high, may offer a simple, inexpensive distinction to predict… read more here.
Keywords: blood eosinophil; eosinophil counts; high blood; low high ... See more keywords
Stability of the Blood Eosinophilic Phenotype in Stable and Exacerbated COPD.
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DOI: 10.1016/j.chest.2019.04.012
Abstract: BACKGROUND There is controversy regarding the use of blood eosinophil levels as a biomarker of exacerbation risk and responsiveness of patients to inhaled corticosteroids (ICS). METHODS Patients in stable COPD with Gold Initiative for Chronic… read more here.
Keywords: blood eosinophil; discordance; eosinophil values; blood ... See more keywords
Eosinophilic asthma, according to a blood eosinophil criterion, is associated with disease severity and lack of control among underprivileged urban Brazilians.
Sign Up to like & getrecommendations! Published in 2018 at "Respiratory medicine"
DOI: 10.1016/j.rmed.2018.10.025
Abstract: BACKGROUND Asthma is a syndrome with multiple phenotypes. Peripheral blood eosinophil counts might be the ideal biomarker to identify subjects with eosinophilic asthma. It is available, inexpensive, and it is associated with eosinophilia in sputum.… read more here.
Keywords: blood eosinophil; control; eosinophilic asthma; severity ... See more keywords
Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-94835-9
Abstract: Blood eosinophil count is a useful measure in asthma or COPD management. Recent epidemiological studies revealed that body mass index (BMI) is positively associated with eosinophil counts. However, few studies focused on the role of… read more here.
Keywords: blood eosinophil; eosinophil counts; genetic background; study ... See more keywords
Biomarkers for differentiation of patients with asthma and chronic obstructive pulmonary disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Asthma"
DOI: 10.1080/02770903.2017.1391281
Abstract: ABSTRACT Objective: Asthma and chronic obstructive pulmonary disease (COPD) are airflow limitation diseases with similar clinical manifestations but different pathophysiologic mechanisms. To implement the appropriate treatment, it is important to distinguish between asthma and COPD… read more here.
Keywords: blood eosinophil; eosinophil counts; feno levels; patients asthma ... See more keywords
Demographic and Clinical Characteristics of COPD Patients at Different Blood Eosinophil Levels in the UK Clinical Practice Research Datalink
Sign Up to like & getrecommendations! Published in 2018 at "COPD: Journal of Chronic Obstructive Pulmonary Disease"
DOI: 10.1080/15412555.2018.1441275
Abstract: ABSTRACT Blood eosinophil count may be a useful biomarker for predicting response to inhaled corticosteroids and exacerbation risk in chronic obstructive pulmonary disease (COPD) patients. The optimal cut point for categorizing blood eosinophil counts in… read more here.
Keywords: copd patients; blood eosinophil; eosinophil count;
Blood Eosinophil Counts, Withdrawal of Inhaled Corticosteroids and Risk of COPD Exacerbations and Mortality in the Clinical Practice Research Datalink (CPRD)
Sign Up to like & getrecommendations! Published in 2019 at "COPD: Journal of Chronic Obstructive Pulmonary Disease"
DOI: 10.1080/15412555.2019.1608172
Abstract: Abstract Although recently introduced in the pharmacological treatment algorithm of chronic obstructive pulmonary disease (COPD), there is a need for more data supporting the use of blood eosinophil counts as a biomarker to guide inhaled… read more here.
Keywords: blood eosinophil; risk; eosinophil counts; mortality ... See more keywords
Prognostic Value of Colonic Tissue and Blood Eosinophils in Ulcerative Colitis
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DOI: 10.1093/ibd/izac044
Abstract: Abstract Background It has been suggested that eosinophils may be a prognostic marker of disease outcome in ulcerative colitis (UC), but conflicting data exist. The objective was to investigate the extent of mucosal eosinophils and… read more here.
Keywords: blood; blood eosinophil; eosinophil count; tissue ... See more keywords
A Phase 1 study of the long-acting anti-IL-5 monoclonal antibody GSK3511294 in patients with asthma.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15002
Abstract: AIMS GSK3511294 is a humanized anti-interleukin (IL)-5 monoclonal antibody (mAb) engineered for extended half-life and improved IL-5 affinity versus other anti-IL-5 mAbs. This study examined its safety, tolerability, pharmacokinetics (PK) and effect on blood eosinophil… read more here.
Keywords: gsk3511294; blood eosinophil; study; monoclonal antibody ... See more keywords
Blood eosinophil count in the diagnosis of allergic‐like rhinitis with chronic rhinosinusitis
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Otolaryngology"
DOI: 10.1111/coa.13990
Abstract: Allergic rhinitis (AR) and nonallergic rhinitis (NAR) often are comorbid with chronic rhinosinusitis (CRS). Finding a convenient test that distinguishes these complex conditions is helpful for effective treatment. We aimed to analyse blood parameter differences… read more here.
Keywords: blood eosinophil; chronic rhinosinusitis; eosinophil count; rhinitis ... See more keywords