Teriflunomide induces a tolerogenic bias in blood immune cells of MS patients
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.711
Abstract: Teriflunomide, a disease‐modifying treatment approved for multiple sclerosis (MS), inhibits reversibly dihydroorotate dehydrogenase, an enzyme involved in de novo pyrimidine biosynthesis and down‐regulates proliferation of activated lymphocytes. We aimed to study the impact of this… read more here.
Keywords: blood immune; tolerogenic bias; induces tolerogenic; immune cells ... See more keywords
Machine learning predicts cancer subtypes and progression from blood immune signatures
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0264631
Abstract: Clinical adoption of immune checkpoint inhibitors in cancer management has highlighted the interconnection between carcinogenesis and the immune system. Immune cells are integral to the tumour microenvironment and can influence the outcome of therapies. Better… read more here.
Keywords: blood immune; immune signatures; tumour; blood ... See more keywords
5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.967921
Abstract: Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis. Dysregulation of 5-Methylcytosine (m5C) RNA has gradually been reported in various cancers, but… read more here.
Keywords: blood immune; diagnosis; immune cells; blood ... See more keywords
Monitoring Blood Immune Cells in Patients with Advanced Small Cell Lung Cancer Undergoing a Combined Immune Checkpoint Inhibitor/Chemotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020190
Abstract: In this exploratory prospective observational study on 40 small cell lung cancer (SCLC) patients treated with a combination of chemotherapy and immune checkpoint inhibitors, blood immune cells were characterized by multi-color flow cytometry at the… read more here.
Keywords: lung cancer; cell; blood immune;
Peripheral blood immune cell-based biomarkers in anti-PD-1/PD-L1 therapy
Sign Up to like & getrecommendations! Published in 2020 at "Immune Network"
DOI: 10.4110/in.2020.20.e8
Abstract: Immune checkpoint blockade targeting PD-1 and PD-L1 has resulted in unprecedented clinical benefit for cancer patients. Anti-PD-1/PD-L1 therapy has become the standard treatment for diverse cancer types as monotherapy or in combination with other anti-cancer… read more here.
Keywords: therapy; peripheral blood; anti therapy; blood immune ... See more keywords