Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aao0935
Abstract: This Review discusses invasive and noninvasive therapeutic delivery methods to the inner ear and challenges presented by the blood-labyrinth barrier. Permanent hearing loss affects more than 5% of the world’s population, yet there are no… read more here.
Keywords: delivery; blood labyrinth; inner ear; labyrinth barrier ... See more keywords
Lack of NHE6 and Inhibition of NKCC1 Associated With Increased Permeability in Blood Labyrinth Barrier-Derived Endothelial Cell Layer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.862119
Abstract: Acoustic trauma, autoimmune inner ear disease, and presbycusis feature loss of the integrity of the blood-labyrinth barrier (BLB). Normal BLB function depends on endothelial structural integrity, which is supported and maintained by tight junctions and… read more here.
Keywords: blb derived; blood labyrinth; labyrinth barrier; permeability ... See more keywords