Chlorogenic acid improves diabetic retinopathy by alleviating blood‐retinal‐barrier dysfunction via inducing Nrf2 activation
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7401
Abstract: As one of the major diabetic microvascular complications, diabetic retinopathy (DR) is mainly initiated by the blood‐retinal barrier (BRB) dysfunction. Chlorogenic acid (CGA) is a natural polyphenolic compound in Lonicerae Japonicae Flos, which traditionally has… read more here.
Keywords: blood retinal; nrf2 activation; barrier; dysfunction ... See more keywords
Silencing Nogo-B improves the integrity of blood-retinal barrier in diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.10.024
Abstract: OBJECTIVE To examine the mechanisms of Nogo-B (RTN4B) in the protection of blood-retinal barrier in experimental diabetic retinopathy. METHODS The level of Nogo-B in vitreous and plasma samples was detected with ELISA. Diabetes was induced… read more here.
Keywords: blood retinal; retinal barrier; diabetic retinopathy; silencing nogo ... See more keywords
C1q/TNF‐related protein‐9 attenuates retinal inflammation and protects blood–retinal barrier in db/db mice
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.04.012
Abstract: ABSTRACT C1q/TNF‐related protein‐9(CTRP9) is an adipose cytokine, a closest adiponectin paralog, which has anti‐inflammatory, antioxidant, vasodilation and anti‐atherosclerosis effects. In addition, it can increase insulin sensitivity, decrease blood glucose level and inhibit the apoptosis of… read more here.
Keywords: retinal barrier; protein; blood retinal; c1q tnf ... See more keywords
Shear stress modulates inner blood retinal barrier phenotype.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107751
Abstract: The vascular endothelium responds to the shear stress generated by blood flow and changes function to maintain tissue homeostasis and adapt to injury in pathological conditions. Shear stress in the retinal circulation is altered in… read more here.
Keywords: retinal barrier; blood retinal; shear stress; inner blood ... See more keywords
Transcriptomics analysis of pericytes from retinas of diabetic animals reveals novel genes and molecular pathways relevant to blood-retinal barrier alterations in diabetic retinopathy.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108043
Abstract: Selective pericyte loss, the histological hallmark of early diabetic retinopathy (DR), enhances the breakdown of the blood-retinal barrier (BRB) in diabetes. However, the role of pericytes on BRB alteration in diabetes and the signaling pathways… read more here.
Keywords: retinal barrier; diabetic retinopathy; blood retinal; analysis ... See more keywords
TIM2 modulates retinal iron levels and is involved in blood-retinal barrier breakdown.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108292
Abstract: Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in… read more here.
Keywords: retinal barrier; retinal iron; blood retinal; iron ... See more keywords
Short- and long-term impact of hyperoxia on the blood and retinal cells’ transcriptome in a mouse model of oxygen-induced retinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0598-y
Abstract: Background We aimed to identify global blood and retinal gene expression patterns in murine oxygen-induced retinopathy (OIR), a common model of retinopathy of prematurity, which may allow better understanding of the pathogenesis of this severe… read more here.
Keywords: blood retinal; retinal cells; gene expression; expression ... See more keywords
Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13621-8
Abstract: Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other chronic retinal diseases, results in vasogenic edema and neural tissue damage, causing vision loss. Vasoinhibins are N-terminal fragments of prolactin that prevent… read more here.
Keywords: retinal barrier; blood retinal; permeability; trpv4 ... See more keywords
GLP-1 RA Improves Diabetic Retinopathy by Protecting the Blood-Retinal Barrier through GLP-1R-ROCK-p-MLC Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Research"
DOI: 10.1155/2022/1861940
Abstract: Background GLP-1 receptor agonists (GLP-1RA) are common clinical agents that are clinically protective against diabetic complications, such as diabetic retinopathy (DR). Previous studies have shown that the RhoA/ROCK pathway plays an important role in the… read more here.
Keywords: glp; blood retinal; rock; glp 1ra ... See more keywords
Effect of pyridone agent on blood-retinal barrier in diabetic mice.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2017.06.09
Abstract: AIM To evaluate the therapeutic effect of fluorofenidone on disrupted blood-retinal barrier in the diabetic mice and uncover its underlying mechanism. METHODS db/db mice were randomly chosen for treatment with daily doses of fluorofenidone or… read more here.
Keywords: retinal vascular; retinal barrier; blood retinal; mice ... See more keywords
Transcriptomic Profiling reveals Chemokine CXCL1 as a mediator for Neutrophil Recruitment associated with Blood-Retinal Barrier Alteration in Diabetic Retinopathy.
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes"
DOI: 10.2337/db22-0619
Abstract: Inflammation plays an important role in the pathogenesis of diabetic retinopathy (DR). To precisely define the inflammatory mediators, we examined the transcriptomic profile of human retinal endothelial cells exposed to advanced glycation end products which… read more here.
Keywords: blood retinal; cxcl1; retinal barrier; neutrophil recruitment ... See more keywords