Gut Microbiota Reconstruction Following Host Infection with Blood-stage Plasmodium berghei ANKA Strain in a Murine Model
Sign Up to like & getrecommendations! Published in 2019 at "Current Medical Science"
DOI: 10.1007/s11596-019-2119-y
Abstract: Malaria remains a global health problem. The relationship between Plasmodium spp. and the gut microbiota as well as the impact of Plasmodium spp. on the gut microbiota in vertebrate hosts is unclear. The aim of… read more here.
Keywords: blood stage; berghei anka; stage; gut microbiota ... See more keywords
Identification of potential whole blood MicroRNA biomarkers for the blood stage of adult imported falciparum malaria through integrated mRNA and miRNA expression profiling.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.072
Abstract: Correlating aberrant miRNA levels with imported malaria during the blood stage is required to better understand the in vivo biological and molecular processes that are involved in the response to Plasmodium falciparum infection and to find… read more here.
Keywords: response; expression; blood; blood stage ... See more keywords
Organ-Specific Fate, Recruitment, and Refilling Dynamics of Tissue-Resident Macrophages during Blood-Stage Malaria.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.059
Abstract: Inflammation-induced disappearance of tissue-resident macrophages represents a key pathogen defense mechanism. Using a model of systemic blood-stage malaria, we studied the dynamics of tissue-resident macrophages in multiple organs to determine how they are depleted and… read more here.
Keywords: stage malaria; tissue resident; tissue; blood stage ... See more keywords
Differences in infection patterns of vector-borne blood-stage parasites of sympatric Malagasy primate species (Microcebus murinus, M. ravelobensis)
Sign Up to like & getrecommendations! Published in 2019 at "International Journal for Parasitology: Parasites and Wildlife"
DOI: 10.1016/j.ijppaw.2019.07.003
Abstract: The dynamic relationship of vector-borne parasites, arthropod vectors and their hosts is prone to change under the influence of climate change, global integration, shifting demographics and deforestation. It is therefore essential to better understand parasitism… read more here.
Keywords: vector borne; infection; blood; blood stage ... See more keywords
Characterization of a Plasmodium falciparum PHISTc protein, PF3D7_0801000, in blood- stage malaria parasites.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology international"
DOI: 10.1016/j.parint.2020.102240
Abstract: During intraerythrocytic development Plasmodium falciparum deploys numerous proteins to support erythrocyte invasion, intracellular growth and development, as well as host immune evasion. Since these proteins are key for parasite intraerythrocytic survival and propagation, they represent… read more here.
Keywords: plasmodium falciparum; pf3d7 0801000; blood stage; pf3d7 0801000n ... See more keywords
Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.6b00572
Abstract: The development of new antimalarial therapies is essential, and lowering the barrier of entry for the screening and discovery of new lead compound classes can spur drug development at organizations that may not have large… read more here.
Keywords: blood stage; machine learning; learning models;
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01995
Abstract: A series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives were identified by a phenotype-based high-throughput screening using a blood stage Plasmodium falciparum (Pf) growth inhibition assay. A lead optimization program focused on improving antiplasmodium potency, selectivity against human… read more here.
Keywords: single dose; pharmacology; blood stage; barrier resistance ... See more keywords
A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
Sign Up to like & getrecommendations! Published in 2022 at "NPJ Vaccines"
DOI: 10.1038/s41541-022-00457-1
Abstract: Pre-erythrocytic malaria vaccines that induce high-titer, durable antibody responses can potentially provide protection from infection. Here, we engineered a virus-like particle (VLP)-based vaccine targeting a recently described vulnerable epitope at the N-terminus of the central… read more here.
Keywords: circumsporozoite protein; protection; blood stage; infection ... See more keywords
Host immune evasion strategies of malaria blood stage parasite.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00502d
Abstract: Host immune evasion is a key strategy for the continual survival of many microbial pathogens including Apicomplexan protozoan: Plasmodium spp., the causative agent of Malaria. The malaria parasite has evolved a variety of mechanisms to… read more here.
Keywords: host immune; immune evasion; blood stage; evasion strategies ... See more keywords
Interpreting challenge data from early phase malaria blood stage vaccine trials
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2018.1435278
Abstract: ABSTRACT Introduction: As the quest for an effective blood stage malaria vaccine continues, there is increasing reliance on the use of controlled human malaria infections (CHMI) in non-endemic settings to test vaccine efficacy at the… read more here.
Keywords: data early; malaria; vaccine trials; blood stage ... See more keywords
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.14.496138
Abstract: The malaria parasite Plasmodium falciparum synthesizes significant amounts of phospholipids to meet the demands of replication within red blood cells. De novo phosphatidylcholine (PC) biosynthesis via the Kennedy pathway is essential, requiring choline that is… read more here.
Keywords: choline; malaria parasite; blood stage; blood ... See more keywords