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Published in 2022 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2143260
Abstract: ABSTRACT Background Inclacumab is a recombinant, fully human, immunoglobulin IgG4 monoclonal antibody that selectively binds to P-selectin. Initially discovered and developed by Roche through phase 2 clinical studies in peripheral arterial disease and coronary artery…
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Keywords:
analytical comparability;
roche;
inclacumab;
global blood ... See more keywords
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Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-129282
Abstract: Sickle Cell Disease (SCD) is characterized by hemolytic anemia, vaso-occlusion, and progressive end-organ damage. The underlying mechanism of SCD is the polymerization of sickle hemoglobin (HbS) that occurs when sickle erythrocytes (SS RBCs) are partially…
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Keywords:
affinity;
tissue;
global blood;
blood therapeutics ... See more keywords