Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in immunology"
DOI: 10.1016/j.smim.2017.08.005
Abstract: For several decades, the leukotriene pathways have been implicated as playing a central role in the pathophysiology of asthma. The presence and elevation of numerous metabolites in the blood, sputum, and bronchoalveolar lavage fluid from… read more here.
Keywords: importance; ltb4 blt1; leukotriene; blt1 ... See more keywords
Leukotriene B4-receptor-1 mediated host response shapes gut microbiota and controls colon tumor progression
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1361593
Abstract: ABSTRACT Inflammation and infection are key promoters of colon cancer but the molecular interplay between these events is largely unknown. Mice deficient in leukotriene B4 receptor1 (BLT1) are protected in inflammatory disease models of arthritis,… read more here.
Keywords: blt1; host response; colon tumor; mice ... See more keywords
Intestinal epithelial BLT1 promotes mucosal repair
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.162392
Abstract: Acute and chronic intestinal inflammation is associated with epithelial damage, resulting in mucosal wounds in the forms of erosions and ulcers in the intestinal tract. Intestinal epithelial cells (IECs) and immune cells in the wound… read more here.
Keywords: wound repair; blt1; epithelial blt1; blt1 promotes ... See more keywords
The LTB4–BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.217422
Abstract: ABSTRACT Neutrophils sense and respond to diverse chemotactic cues through G-protein-coupled receptors (GPCRs). However, the precise trafficking dynamics of chemoattractant GPCRs during neutrophil activation and chemotaxis remain unclear. Here, by using small-molecule inhibitors and CRISPR-based… read more here.
Keywords: chemoattractant gpcrs; blt1; polarized trafficking; chemotaxis ... See more keywords