12-HETE Is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202515897
Abstract: Thoracic aortic dissection (TAD), a life-threatening vascular emergency requiring urgent pharmacological intervention, prompted investigation into arachidonic acid metabolites based on their established roles in inflammation and vascular homeostasis. Through comprehensive plasma metabolomics analysis performed in… read more here.
Keywords: blt2; dissection; hete endogenous; dissection rupture ... See more keywords
Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01617
Abstract: The leukotriene B4 receptor 2 (BLT2) is a G-protein coupled receptor, which is endogenously activated by 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT). BLT2 is gaining attention as a potential therapeutic target involved in various pathologies including diabetic wound… read more here.
Keywords: chemical probe; blt2; blt2 activation; scaffold hopping ... See more keywords
BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "BMB Reports"
DOI: 10.5483/bmbrep.2018.51.8.127
Abstract: Triple-negative breast cancer (TNBC) is considered to be a notorious type of cancer due to its aggressive metastatic potential and poor prognosis. Recent evidence suggests that BLT2, a low-affinity LTB4 receptor is critically associated with… read more here.
Keywords: negative breast; blt2; breast cancer; cancer ... See more keywords