The Blunt End: Surgical Challenges of Gene Therapy for Inherited Retinal Diseases.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2018.08.038
Abstract: PURPOSE To review barriers to effective transduction of cells in the subretinal plane during gene therapy surgery for inherited retinal dystrophies (IRD). DESIGN Perspective. METHODS Case-based learning in clinical trials and commercial applications of gene… read more here.
Keywords: end surgical; gene therapy; blunt end; inherited retinal ... See more keywords
Photo-switching of blunt-end stacking between DNA strands immobilized on gold nanoparticles.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc05085g
Abstract: End-to-end intermolecular interaction between double-stranded DNAs grafted onto individual nanoparticles is regulated by terminal base pairing/unpairing triggered by the photo-isomerization of an azobenzene moiety inserted in the vicinity of the DNA terminal. This is the… read more here.
Keywords: end; photo switching; blunt end; end stacking ... See more keywords
Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14071407
Abstract: Pathogen-associated molecular patterns, including cytoplasmic DNA and double-strand (ds)RNA trigger the induction of interferon (IFN) and antiviral states protecting cells and organisms from pathogens. Here we discovered that the transfection of human airway cell lines… read more here.
Keywords: strand; blunt end; viral effects; rna ... See more keywords