Analysis of BMAA enantiomers in cycads, cyanobacteria, and mammals: in vivo formation and toxicity of d-BMAA
Sign Up to like & getrecommendations! Published in 2017 at "Amino Acids"
DOI: 10.1007/s00726-017-2445-y
Abstract: Chronic dietary exposure to the cyanobacterial toxin β-N-methylamino-l-alanine (BMAA) triggers neuropathology in non-human primates, providing support for the theory that BMAA causes a fatal neurodegenerative illness among the indigenous Chamorro people of Guam. However, since… read more here.
Keywords: enantiomers cycads; analysis bmaa; bmaa enantiomers; toxicity ... See more keywords
A tRNA t6A modification system contributes to the sensitivity towards the toxin β-N-methylamino-L-alanine (BMAA) in the cyanobacterium Anabaena sp. PCC 7120.
Sign Up to like & getrecommendations! Published in 2022 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2022.106121
Abstract: Cyanobacteria are oxygen-evolving photosynthetic autotrophs essential for nutrient cycling in the environment. They possess multiple control mechanisms for their cellular activities in order to adapt to the environment. While protein translation is essential for cell… read more here.
Keywords: alanine bmaa; cyanobacterium anabaena; bmaa; t6a ... See more keywords
L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.01.007
Abstract: Background: L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) is a non‐proteinic amino acid, that is neurotoxic in vitro and in animals, and is implicated in the causation of amyotrophic lateral sclerosis and parkinsonism‐dementia complex (ALS‐PDC) on Guam. Given that natural… read more here.
Keywords: alanine bmaa; alkylating agent; bgr methylamino; bmaa ... See more keywords
Behavior and gene expression in the brain of adult self-fertilizing mangrove rivulus fish (Kryptolebias marmoratus) after early life exposure to the neurotoxin β-N-methylamino-L-alanine (BMAA).
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2020.04.007
Abstract: β-N-methylamino-L-alanine (BMAA), a neurotoxin naturally produced by cyanobacteria, diatoms and dinoflagellates, constitutes a serious environmental and health threat especially during acute blooms, which are becoming more frequent. This neurotoxin is implicated in several neurodegenerative diseases… read more here.
Keywords: alanine bmaa; expression; neurotoxin; bmaa ... See more keywords
BMAA‐protein interactions: A possible new mechanism of toxicity
Sign Up to like & getrecommendations! Published in 2018 at "Toxicon"
DOI: 10.1016/j.toxicon.2018.01.011
Abstract: ABSTRACT &bgr;‐N‐methylamino‐L‐alanine (BMAA) has been shown to accumulate in organisms by associating with host proteins. It has been proposed that this association is the result of misincorporation of BMAA into the primary structure of proteins,… read more here.
Keywords: protein; bmaa protein; mechanism toxicity; bmaa ... See more keywords
Chiral analysis of β-methylamino alanine (BMAA) enantiomers after (+)-1-(9-fluorenyl)-ethyl chloroformate (FLEC) derivatization and LC-MS/MS
Sign Up to like & getrecommendations! Published in 2019 at "Analytical Methods"
DOI: 10.1039/c8ay02287a
Abstract: A developed method for chiral analysis of neurotoxin β-methylamino alanine (BMAA) allowed detection of d-BMAA in cycad seed samples. read more here.
Keywords: methylamino alanine; alanine bmaa; chiral analysis; bmaa ... See more keywords
Improved quantification of the cyanobacteria metabolite, β-methylamino-l-alanine (BMAA) using HPLC-MS/MS detection of its dansyl chloride derivative referenced to a15N-labeled internal standard
Sign Up to like & getrecommendations! Published in 2019 at "Analytical Methods"
DOI: 10.1039/c9ay00284g
Abstract: Historic disagreement regarding the prevalence and abundance of BMAA may be due in part to false-negative results arising from deuterated internal standards and the derivatization conditions used in prior studies. read more here.
Keywords: methylamino alanine; quantification cyanobacteria; improved quantification; metabolite methylamino ... See more keywords
Induction of a neurotoxin in diatoms by iron limitation via cysteine synthase
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2424843122
Abstract: Significance Neurodegenerative diseases like Alzheimer’s disease (AD) and amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) represent an increasing global health crisis. Understanding the biochemical causes of these diseases thus merits high priority. The neurotoxin β-N-methylamino-L-alanine (BMAA)… read more here.
Keywords: induction neurotoxin; neurotoxin diatoms; bmaa; neurotoxin ... See more keywords
Microcystins, BMAA and BMAA isomers in 100-year-old Antarctic cyanobacterial mats collected during Captain R.F. Scott’s Discovery Expedition
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Phycology"
DOI: 10.1080/09670262.2018.1442587
Abstract: ABSTRACT Microcystins (MCN), β-N-methylamino-L-alanine (BMAA) and anatoxin-a were investigated in Antarctic cyanobacterial mats collected from Ross Island and the McMurdo Ice Shelf, East Antarctica during Captain Scott’s ‘Discovery’ National Antarctic Expedition (1901–1904). Ultra-performance liquid chromatography-photodiode… read more here.
Keywords: bmaa isomers; mats collected; antarctic cyanobacterial; captain scott ... See more keywords
The biotoxin BMAA promotes dysfunction via distinct mechanisms in neuroblastoma and glioblastoma cells
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0278793
Abstract: Chronic exposure to the Cyanobacteria biotoxin Beta-methylamino-L-alanine (BMAA) has been associated with development of a sporadic form of ALS called Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC), as observed within certain Indigenous populations of Guam and Japan.… read more here.
Keywords: glioblastoma cells; bmaa; bmaa promotes; biotoxin bmaa ... See more keywords
Evaluation of cyanotoxin L-BMAA effect on α-synuclein and TDP43 proteinopathy
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1360068
Abstract: The complex interplay between genetic and environmental factors is considered the cause of neurodegenerative diseases including Parkinson’s disease (PD) and Amyotrophic Lateral Sclerosis (ALS). Among the environmental factors, toxins produced by cyanobacteria have received much… read more here.
Keywords: evaluation cyanotoxin; cyanotoxin bmaa; synuclein tdp43; bmaa ... See more keywords