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   Articles with "bmal1" as a keyword



Circadian clock gene BMAL1 controls testosterone production by regulating steroidogenesis‐related gene transcription in goat Leydig cells

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recommendations! Published in 2021 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30334

Abstract: Testosterone is produced by Leydig cells (LCs) and undergoes diurnal changes in serum levels in rats, mice, and humans, but little is known in goats. The present study revealed that goat serum testosterone levels displayed… read more here.

Keywords: bmal1; circadian clock; testosterone production; goat lcs ... See more keywords

Smad3 and Bmal1 regulate p21 and S100A4 expression in myocardial stromal fibroblasts via TNF-α

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recommendations! Published in 2017 at "Histochemistry and Cell Biology"

DOI: 10.1007/s00418-017-1597-x

Abstract: Bmal1, a clock gene, is associated with depression, hypertrophy, metabolic syndrome and diabetes. Smad3, which is involved in the TGF-β signaling pathway, plays an important role in the regulation of tumor progression, fibrosis, obesity and… read more here.

Keywords: smad3 bmal1; bmal1; p21 s100a4; expression ... See more keywords

Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathway

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recommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-024-05753-y

Abstract: Acute myeloid leukemia (AML) is a refractory hematologic malignancy that poses a serious threat to human health. Exploring alternative therapeutic strategies capable of inducing alternative modes of cell death, such as ferroptosis, holds great promise… read more here.

Keywords: bmal1; resistance; acute myeloid; ferroptosis ... See more keywords

NSP-C contributes to the upregulation of CLOCK/BMAL1-mediated transcription

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recommendations! Published in 2018 at "Cytotechnology"

DOI: 10.1007/s10616-018-0266-9

Abstract: The bHLH-PAS transcription factors clock circadian regulator (CLOCK) and brain and muscle ARNT-like protein 1 (BMAL1) play essential roles in the generation of circadian gene expression rhythms through the activation of E-box-mediated transcription. Importantly, circadian… read more here.

Keywords: bmal1; clock bmal1; bmal1 mediated; clock ... See more keywords
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BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy

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recommendations! Published in 2020 at "Protein & Cell"

DOI: 10.1007/s13238-020-00713-x

Abstract: Dysregulation of circadian rhythms associates with cardiovascular disorders. It is known that deletion of the core circadian gene Bmal1 in mice causes dilated cardiomyopathy. However, the biological rhythm regulation system in mouse is very different… read more here.

Keywords: protein; bmal1; function; mitochondrial fission ... See more keywords

The Circadian Clock Gene Bmal1 Controls Thyroid Hormone-Mediated Spectral Identity and Cone Photoreceptor Function.

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.09.069

Abstract: Circadian clocks regulate various aspects of photoreceptor physiology, but their contribution to photoreceptor development and function is unclear. Cone photoreceptors are critical for color vision. Here, we define the molecular function of circadian activity within… read more here.

Keywords: bmal1; cone photoreceptor; photoreceptor; function ... See more keywords

Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 cooperates with glycogen synthase kinase-3β to regulate osteogenesis of bone-marrow mesenchymal stem cells in type 2 diabetes

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recommendations! Published in 2017 at "Molecular and Cellular Endocrinology"

DOI: 10.1016/j.mce.2016.10.001

Abstract: Type 2 diabetes mellitus (T2DM) is associated with inhibited osteogenesis of bone marrow mesenchymal stem cells (BMSCs). Brain and muscle ARNT-like protein 1 (BMAL1) has been linked to the T2DM-related bone remodeling, however, the specific… read more here.

Keywords: bmal1; kinase; bone; type diabetes ... See more keywords
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Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice

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recommendations! Published in 2021 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2021.101202

Abstract: Objective Impaired circadian clocks can cause obesity, but their pathophysiological role in brown adipose tissue (BAT), a major tissue regulating energy metabolism, remains unclear. To address this issue, we investigated the effects of complete disruption… read more here.

Keywords: bmal1; brown adipocyte; bat; adipocyte specific ... See more keywords

Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1

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recommendations! Published in 2021 at "Translational Psychiatry"

DOI: 10.1038/s41398-021-01212-1

Abstract: Disrupted-in-schizophrenia 1 (DISC1) is a scaffold protein that has been implicated in multiple mental disorders. DISC1 is known to regulate neuronal proliferation, signaling, and intracellular calcium homeostasis, as well as neurodevelopment. Although DISC1 was linked… read more here.

Keywords: bmal1; disc1; disrupted schizophrenia; circadian rhythm ... See more keywords

Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis.

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recommendations! Published in 2021 at "Acta pharmacologica Sinica"

DOI: 10.1038/s41401-021-00658-9

Abstract: Hepatic stellate cells (HSCs) play an important role in the initiation and development of liver fibrogenesis, and abnormal glucose metabolism is increasingly being considered a crucial factor controlling phenotypic transformation in HSCs. However, the role… read more here.

Keywords: phenotypic transformation; bmal1; glycolysis; liver fibrosis ... See more keywords

Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-44778-2

Abstract: The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role in mouse melanoma tumor growth. Loss of Bmal1 in YUMM2.1 or B16-F10 melanoma… read more here.

Keywords: bmal1; clock; cell state; immunity ... See more keywords