Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.
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DOI: 10.18632/oncotarget.18973
Abstract: Circadian rhythms are regulated by transcriptional and post-translational feedback loops generated by appropriate functions of clock proteins. Rhythmic degradation of the circadian clock proteins is critical for maintenance of the circadian oscillations. Notably, circadian clock… read more here.
Keywords: circadian rhythms; piwil2; bmal1 clock; cancer ... See more keywords
Polymorphisms in ARNTL/BMAL1 and CLOCK Are Not Associated with Multiple Sclerosis in Spanish Population
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DOI: 10.3390/biology11101417
Abstract: Simple Summary Autoimmune diseases such as multiple sclerosis develop from an undefined mixture of environmental factors interacting with dozens to hundreds of genetic variations that confer risk. In the particular case of multiple sclerosis, shift… read more here.
Keywords: sclerosis; arntl bmal1; population; multiple sclerosis ... See more keywords
Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells
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DOI: 10.3390/ijms222011186
Abstract: Roles of Clock genes and the bone morphogenetic protein (BMP) system in the regulation of gonadotropin secretion by gonadotropin-releasing hormone (GnRH) were investigated using mouse gonadotropin LβT2 cells. It was found that luteinizing hormone (LH)β… read more here.
Keywords: phase; expression; bmal1 clock; gnrh ... See more keywords
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells
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DOI: 10.3390/ijms23105611
Abstract: Metabolic disorders are closely associated with the dysregulation of circadian rhythms. Many bioactive components with lipid metabolism-regulating effects have been reported to function through circadian clock-related mechanisms. As the main pungent principle of black pepper,… read more here.
Keywords: pip; genes bmal1; clock; dysregulation ... See more keywords