BMAL1 knockdown promoted apoptosis and reduced testosterone secretion in TM3 Leydig cell line.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144672
Abstract: Brain and muscle Arnt-like protein-1 (BMAL1) is a clock gene that plays an important role in hormone secretion and apoptosis, but its effect on Leydig cells is unidentified. Here the role of BMAL1 in apoptosis… read more here.
Keywords: secretion; apoptosis; testosterone secretion; leydig ... See more keywords
BMAL1 regulates osteoblast differentiation through mTOR/GSK3β/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-22-0181
Abstract: Bone mass declines with age and its maintenance is tightly linked to osteoblasts (crucial bone-building cells). Although disruption of peripheral circadian clock is involved in various pathologies including aging-related diseases, evidence regarding how peripheral clock… read more here.
Keywords: bmal1 knockdown; gsk3 catenin; differentiation; osteoblast differentiation ... See more keywords
Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.937608
Abstract: Objectives The neural activity of the left stellate ganglion (LSG) is closely related to the occurrence of ventricular arrhythmias (VAs). Bmal1 modulates genes associated with neural activity in the central nervous system. However, few studies… read more here.
Keywords: ischemia; bmal1 knockdown; activity; ventricular arrhythmias ... See more keywords