Defective circadian control in mesenchymal cells reduces adult bone mass in mice by promoting osteoclast function.
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DOI: 10.1016/j.bone.2019.01.016
Abstract: Serum bone turnover markers show diurnal variation in humans, suggesting that circadian rhythms contribute to normal bone physiology. This conclusion is corroborated by bone phenotypes in mice with genetic disruption of the circadian molecular clock… read more here.
Keywords: prx1 cre; bmal1f; bone; mice ... See more keywords