A specific haplotype in potential miRNAs binding sites of secreted frizzled-related protein 1 (SFRP1) is associated with BMD variation in osteoporosis.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.07.061
Abstract: PURPOSE Osteoporosis is an important multifactorial disease which is largely influenced by Wnt signaling pathway. Considering regulatory single nucleotide polymorphisms in Wnt signaling pathway may pave the road of understanding the genetic basis of predisposition… read more here.
Keywords: bmd variation; spine bmd; sfrp1; lumbar spine ... See more keywords
Multiple polygenic scores improve bone mineral density prediction in an independent sample of Caucasian women.
Sign Up to like & getrecommendations! Published in 2022 at "Postgraduate medical journal"
DOI: 10.1136/postgradmedj-2021-139722
Abstract: PURPOSE OF THE STUDY To determine if multiple Genetic Risk Scores (GRSs) improve bone mineral density (BMD) prediction over single GRS in an independent sample of Caucasian women. STUDY DESIGN Based on summary statistics of… read more here.
Keywords: bmd; bmd variation; risk; model ... See more keywords