Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12914
Abstract: Rhabdomyosarcoma (RMS) is an aggressive pediatric soft tissue sarcoma. There are two main subtypes of RMS, alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma. ARMS typically encompasses fusion‐positive rhabdomyosarcoma, which expresses either PAX3‐FOXO1 or PAX7‐FOXO1 fusion proteins.… read more here.
Keywords: epigenetic regulator; target; rhabdomyosarcoma; alveolar rhabdomyosarcoma ... See more keywords
Anticancer effects of miR‐200c in colorectal cancer through BMI1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27330
Abstract: Colorectal cancer (CRC) is one of the most leading cancer deaths throughout the world. MiR‐200c has been shown to have a critical role in cancer initiation and progression. In this study, we investigated the miR‐200c… read more here.
Keywords: colorectal cancer; crc tissues; expression; mir 200c ... See more keywords
Expression of tumour transcription factor GLI1 in canine mammary tumours tissue
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.830
Abstract: Abstract Background Mammary tumor is one of the most common diseases of canine in pet clinics. Objectives This study investigates the distribution and expression of the tumor transcription factor GLI1 and the downstream proteins, Bmi1… read more here.
Keywords: gli1; expression; canine mammary; bmi1 ... See more keywords
Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03192-1
Abstract: PurposeGlioblastoma (GBM) is the most aggressive adult brain cancer, with a 15 month median survivorship attributed to the existence of treatment-refractory brain tumor initiating cells (BTICs). In order to better understand the mechanisms regulating the tumorigenic… read more here.
Keywords: tumor initiating; brain tumor; stem; brain ... See more keywords
Polycomb complex protein BMI1 confers resistance to tamoxifen in estrogen receptor positive breast cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.03.048
Abstract: We report that BMI1 promotes tamoxifen resistance in estrogen receptor (ER)-positive breast cancer (BC). BMI1 overexpression conferred MCF7 and TD47 cells resistance to tamoxifen; BMI1 knockdown sensitized the process. In MCF7-derived tamoxifen resistant cells, BMI1 expression… read more here.
Keywords: resistance tamoxifen; estrogen receptor; bmi1; cancer ... See more keywords
Expression and therapeutic targeting of BMI1 in canine gliomas.
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary and comparative oncology"
DOI: 10.1111/vco.12852
Abstract: The BMI1 proto-oncogene, polycomb ring finger protein (BMI1) is a key component of the epigenetic polycomb repressor complex 1, and has been associated with aggressive behavior and chemotherapeutic resistance in various malignances including human gliomas.… read more here.
Keywords: targeting bmi1; expression; gliomas; bmi1 ... See more keywords
Abstract 3673: The BMI1/Sp1/IGF1R pathway mediates pemetrexed resistance in non-small cell lung cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-3673
Abstract: Background: Lung cancer is the leading cause of cancer death in Taiwan and worldwide and non-small cell lung cancers (NSCLCs) account for more than 85% of lung cancers. Pemetrexed is approved for several steps of… read more here.
Keywords: lung; sp1; cancer; resistance ... See more keywords
Abstract C56: Bmi1 is widely expressed in acini and regulates Kras-driven transcription factor networks in early pancreatic neoplasia
Sign Up to like & getrecommendations! Published in 2019 at "Robotics and Autonomous Systems"
DOI: 10.1158/1538-7445.panca19-c56
Abstract: Rare acinar cells expressing Bmi1, a component of the Polycomb Repressor Complex 1 (PRC1), represent a reservoir of cells contributing to pancreatic repair during injury and stress. This is marked by acinar-ductal metaplasia (ADM), a… read more here.
Keywords: creer; pancreatic neoplasia; acinar cells; kras driven ... See more keywords
Overexpressed Sirt1 in MSCs Promotes Dentin Formation in Bmi1-Deficient Mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Dental Research"
DOI: 10.1177/0022034518781509
Abstract: Sirt1 promotes odontoblastic gene expression in human dental pulp cells, whereas the inhibition of Sirt1 downregulates the expression of those genes. To investigate whether the overexpression of Sirt1 in mesenchymal stem cells (MSCs) driven by… read more here.
Keywords: sirt1; bmi1 deficient; dentin formation; mice ... See more keywords
MicroRNA-139-5p inhibits bladder cancer proliferation and self-renewal by targeting the Bmi1 oncogene
Sign Up to like & getrecommendations! Published in 2017 at "Tumor Biology"
DOI: 10.1177/1010428317718414
Abstract: MiR-139-5p has been reported to be overexpressed in many types of cancers, but its role in bladder cancer has not been elucidated yet. Here, we report that miR-139-5p functions as a tumor suppressor in bladder… read more here.
Keywords: bladder cancer; mir 139; self renewal; cancer ... See more keywords
Genetic or Pharmacological Inhibition of the Polycomb Group Protein BMI1 Impairs Leukemic Transformation Mediated By the CALM-AF10 Fusion Oncoprotein
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-115552
Abstract: A subset of acute myeloid and lymphoid leukemia cases harbor a t(10;11)(p13;q14) translocation resulting in the CALM-AF10 fusion gene. Standard chemotherapeutic strategies are not very effective in treating patients with CALM-AF10 fusions. Hence, there is… read more here.
Keywords: af10 fusion; af10; bmi1; calm af10 ... See more keywords