BML‐111 inhibits osteoclast differentiation by suppressing the MAPK and NF‐κB pathways, alleviating deterioration of the knee joints in a CIA rat model
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biology International"
DOI: 10.1002/cbin.11990
Abstract: Irreversible destruction of joints is the hallmark of rheumatoid arthritis (RA). Osteoclasts are the only bone‐resorbing cells and play an important role in joint rebuilding. BML‐111 (5(S),6(R),7‐trihydroxyheptanoic acid methyl ester, C8H16O5) is a synthetic lipoxin… read more here.
Keywords: differentiation; rat model; knee joints; bml 111 ... See more keywords
BML-111, the lipoxin A4 agonist, modulates VEGF or CoCl2-induced migration, angiogenesis and permeability in tumor-derived endothelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.12.007
Abstract: Tumor angiogenesis plays a vital role in carcinogenesis, cancer progression, and metastasis. Lipoxin A4 (LXA4) is an endogenously-produced family of effective anti-inflammatory with a potent inhibitory effect on angiogenesis. However, BML-111, a LXA4 agonist, its… read more here.
Keywords: angiogenesis; permeability; vegf cocl2; bml 111 ... See more keywords
Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07485-1
Abstract: Psoriasis is a chronic inflammatory skin disease that affects 2–3% of the global population, and there is still no known possibility of a cure. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual… read more here.
Keywords: hmgb1 translocation; expression; lipoxin; psoriasis ... See more keywords
The Effect of BML-111 in Preeclampsia Rat Model Induced by the Low Dose of Cadmium Chloride
Sign Up to like & getrecommendations! Published in 2019 at "AJP Reports"
DOI: 10.1055/s-0039-1693016
Abstract: Aim This article determines the optimal time and dose of cadmium chloride (CdCl 2 ) injected to pregnant rat to establish experimental preeclampsia (PE) model. In addition, the therapeutic potential of BML-111, a lipoxin A4… read more here.
Keywords: dose cadmium; pregnant rats; model; cadmium chloride ... See more keywords
Lipoxin A4 receptor agonist BML-111 induces autophagy in alveolar macrophages and protects from acute lung injury by activating MAPK signaling
Sign Up to like & getrecommendations! Published in 2018 at "Respiratory Research"
DOI: 10.1186/s12931-018-0937-2
Abstract: Acute lung injury (ALI) is a life-threatening lung disease where alveolar macrophages (AMs) play a central role both in the early phase to initiate inflammatory responses and in the late phase to promote tissue repair.… read more here.
Keywords: alveolar macrophages; autophagy ams; bml 111; lung injury ... See more keywords
BML-111 inhibits the inflammatory response and apoptosis of renal tissue in rats with hemorrhagic shock by inhibiting the MAPK pathway.
Sign Up to like & getrecommendations! Published in 2018 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201806_15168
Abstract: OBJECTIVE The effect of lipoxin receptor agonist BML-111 on acute kidney injury and AKI in rats with hemorrhagic shock (HS) and its mechanism were investigated. MATERIALS AND METHODS A model of hemorrhagic shock in Sprague-Dawley… read more here.
Keywords: renal tissue; bml 111; hemorrhagic shock; group ... See more keywords
BML-111 suppresses TGF-β1-induced lung fibroblast activation in vitro and decreases experimental pulmonary fibrosis in vivo
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2018.3914
Abstract: Pulmonary fibrosis is an aggressive end-stage disease. Transforming growth factor-β1 (TGF-β1) mediates lung fibroblast activation and is essential for the progress of pulmonary fibrosis. BML-111, a lipoxinA4 (LXA4) receptor (ALX) agonist, has been reported to… read more here.
Keywords: lung fibroblast; tgf induced; pulmonary fibrosis; activation ... See more keywords