Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip Applications
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202000980
Abstract: Targeted delivery and release of biomolecules, e.g., bone morphogenetic protein (BMP‐2), are gaining high interest due to the application for tissue engineering, diagnostics, surface‐enhanced therapy and lab‐on‐a‐chip. Here, a new hybrid temperature‐responsive system consisting of… read more here.
Keywords: lab chip; release; heat photothermal; therapy lab ... See more keywords
Role of BMP Signaling for the Formation of Auditory Brainstem Nuclei and Large Auditory Relay Synapses
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22661
Abstract: Large excitatory synapses are found at specific points in the neuronal circuits of the auditory brainstem, to enable fast information transfer and the preservation of acoustic timing information. The extracellular cues and signaling mechanisms that… read more here.
Keywords: bmp signaling; brainstem nuclei; bmp; auditory brainstem ... See more keywords
Differential expression of BMP inhibitors gremlin and noggin in Hydra suggests distinct roles during budding and patterning of tentacles
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Dynamics"
DOI: 10.1002/dvdy.238
Abstract: Mechanisms regulating BMP and Wnt pathways and their interactions are not well studied in Hydra. read more here.
Keywords: bmp; differential expression; hydra; bmp inhibitors ... See more keywords
An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.478
Abstract: Pulmonary arterial hypertension (PAH) is an often fatal condition, the primary pathology of which involves loss of pulmonary vascular perfusion due to progressive aberrant vessel remodeling. The reduced capacity of the pulmonary circulation places increasing… read more here.
Keywords: bmp signaling; arterial hypertension; bmp; pulmonary arterial ... See more keywords
Gremlin2 Suppression Increases the BMP‐2‐Induced Osteogenesis of Human Bone Marrow‐Derived Mesenchymal Stem Cells Via the BMP‐2/Smad/Runx2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25635
Abstract: Osteoblasts are essential for maintaining skeletal architecture and modulating bone microenvironment homeostasis. From numerous associated investigations, the BMP‐2 pathway has been well‐defined as a vital positive modulator of bone homeostasis. Gremlin2 (Grem2) is a bone… read more here.
Keywords: bmp; induced osteogenesis; bmp smad; bone ... See more keywords
IGF‐1 and BMP‐7 synergistically stimulate articular cartilage repairing in the rabbit knees by improving chondrogenic differentiation of bone‐marrow mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27841
Abstract: Knee injury is known as a frequently occurred damage related to sports, which may affect the function of cartilage. This study aims to explore whether Insulin‐like growth factor 1 (IGF‐1) and bone morphogenetic protein‐7 (BMP‐7)‐modified… read more here.
Keywords: bmp; igf bmp; articular cartilage; damage ... See more keywords
Structural basis of BMP‐2 and BMP‐7 interactions with antagonists Gremlin‐1 and Noggin in Glioblastoma tumors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26407
Abstract: In Glioblastoma (GBM) brain tumors, both Gremlin‐1 and Noggin are reported to bind to BMP and inhibit BMP‐signaling, thereby allowing the cell to maintain tumorous morphology. Enlisting the interfacial residues important for protein–protein complex formation… read more here.
Keywords: structural basis; bmp; gremlin noggin; glioblastoma ... See more keywords
Defining early hematopoietic‐fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28272
Abstract: Distinct regions of the primitive streak (PS) have diverse potential to differentiate into several tissues, including the hematopoietic lineage originated from the posterior region of PS. Although various signaling pathways have been identified to promote… read more here.
Keywords: wnt activin; signaling pathways; bmp signaling; bmp ... See more keywords
Soybean Lecithin-Mediated Nanoporous PLGA Microspheres with Highly Entrapped and Controlled Released BMP-2 as a Stem Cell Platform.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201800063
Abstract: Injectable polymer microsphere-based stem cell delivery systems have a severe problem that they do not offer a desirable environment for stem cell adhesion, proliferation, and differentiation because it is difficult to entrap a large number… read more here.
Keywords: stem cell; plga bmp; bmp; bmp microspheres ... See more keywords
Precisely Localized Bone Regeneration Mediated by Marine-Derived Microdroplets with Superior BMP-2 Binding Affinity.
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DOI: 10.1002/smll.202200416
Abstract: Prompt and robust bone regeneration has been clinically achieved using supraphysiological doses of bone morphogenetic protein-2 (BMP-2) to overcome the short half-life and rapid clearance. However, uncontrolled burst release of exogenous BMP-2 causes severe complications… read more here.
Keywords: superior bmp; bmp binding; bmp; bone ... See more keywords
Mesenchymal stem cell expression of SDF‐1β synergizes with BMP‐2 to augment cell‐mediated healing of critical‐sized mouse calvarial defects
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2078
Abstract: Bone has the potential for spontaneous healing. This process, however, often fails in patients with comorbidities. Tissue engineering combining functional cells, biomaterials and osteoinductive cues may provide alternative treatment strategies. We have recently demonstrated that… read more here.
Keywords: bmp; bone; healing critical; sdf ... See more keywords