Gremlin2 Suppression Increases the BMP‐2‐Induced Osteogenesis of Human Bone Marrow‐Derived Mesenchymal Stem Cells Via the BMP‐2/Smad/Runx2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25635
Abstract: Osteoblasts are essential for maintaining skeletal architecture and modulating bone microenvironment homeostasis. From numerous associated investigations, the BMP‐2 pathway has been well‐defined as a vital positive modulator of bone homeostasis. Gremlin2 (Grem2) is a bone… read more here.
Keywords: bmp; induced osteogenesis; bmp smad; bone ... See more keywords
MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00688-2
Abstract: Neuronal connectivity is dependent on size and shape of the dendritic arbor. However, mechanisms controlling dendritic arborization, especially in the peripheral nervous system, are not completely understood. Previous studies have shown that bone morphogenetic proteins… read more here.
Keywords: sympathetic neurons; dendritic growth; bmp induced; growth ... See more keywords
Dehydrodiconiferyl alcohol promotes BMP-2-induced osteoblastogenesis through its agonistic effects on estrogen receptor.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.12.079
Abstract: Estrogen deficiency results in an imbalance between the levels of bone-resorping osteoclasts and bone-forming osteoblasts, eventually leading to overall bone loss. Dehydrodiconiferyl alcohol (DHCA), a lignan compound originally isolated from Cucurbita moschata, has been shown… read more here.
Keywords: dhca; induced osteoblastogenesis; bmp induced; osteoblastogenesis ... See more keywords
BMP-2-induced bone formation and neural inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of orthopaedics"
DOI: 10.1016/j.jor.2017.03.003
Abstract: Bone morphogenetic protein-2 (BMP-2), a potent osteoinductive cytokine from the transforming growth factor beta (TGF-β) family, is currently the most commonly used protein-based bone graft substitute. Although clinical use of BMP-2 has significantly increased in… read more here.
Keywords: bone formation; bmp induced; inflammation;
Sclerostin deficiency effectively promotes bone morphogenetic protein-2-induced ectopic bone formation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of periodontal research"
DOI: 10.1111/jre.13134
Abstract: BACKGROUND AND OBJECTIVE Severe periodontitis causes alveolar bone resorption, resulting in tooth loss. Developments of tissue regeneration therapy that can restore alveolar bone mass are desired for periodontal disease. The application of bone morphogenetic protein-2… read more here.
Keywords: induced ectopic; sclerostin deficiency; bone; bmp induced ... See more keywords
Identification of key genes and pathways of BMP-9-induced osteogenic differentiation of mesenchymal stem cells by integrated bioinformatics analysis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-021-02390-w
Abstract: Background The purpose of present study was to identify the differentially expressed genes (DEGs) associated with BMP-9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) by using bioinformatics methods. Methods Gene expression profiles of BMP-9-induced MSCs… read more here.
Keywords: genes pathways; analysis; induced mscs; induced osteogenic ... See more keywords
Selective Retinoic Acid Receptor γ Antagonist 7C is a Potent Enhancer of BMP-Induced Ectopic Endochondral Bone Formation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.802699
Abstract: Bone morphogenetic proteins (BMPs) have been clinically applied for induction of bone formation in musculoskeletal disorders such as critical-sized bone defects, nonunions, and spinal fusion surgeries. However, the use of supraphysiological doses of BMP caused… read more here.
Keywords: bone formation; bone; bmp; bmp induced ... See more keywords