EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways
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DOI: 10.1126/sciadv.aaz6477
Abstract: Polycomb repressive EED protein orchestrates WNT, BMP, and senescence pathways to ensure proper CNS myelination and repair. Mutations in the polycomb repressive complex 2 (PRC2) can cause Weaver-like syndrome, wherein a patient cohort exhibits abnormal… read more here.
Keywords: wnt bmp; cns myelination; bmp; bmp senescence ... See more keywords